Scores & Fixtures 2022 Major League Soccer
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2022-02-26 | 12:30 | LAFC | 2.4 | 3–0 | 0.4 | Rapids | 22,010 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-02-26 | 13:00 | Philadelphia | 1.1 | 1–1 | 1.1 | Minnesota Utd | 17,487 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sat | 2022-02-26 | 15:00 | SJ Earthquakes | 1.1 | 1–3 | 3.0 | NY Red Bulls | 16,146 | PayPal Park | Drew Fischer | Match Report | |
| Sat | 2022-02-26 | 15:30 | Crew | 3.4 | 4–0 | 0.5 | Vancouver W'caps | 18,939 | Lower.com Field | Nima Saghafi | Match Report | |
| Sat | 2022-02-26 | 16:30 | FC Dallas | 1.9 | 1–1 | 1.5 | Toronto FC | 12,233 | Toyota Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-02-26 | 17:00 | Austin | 2.3 | 5–0 | 1.7 | FC Cincinnati | 20,738 | Q2 Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-02-26 | 18:00 | D.C. United | 1.6 | 3–0 | 1.2 | Charlotte | 16,412 | Audi Field | Victor Rivas | Match Report | |
| Sat | 2022-02-26 | 18:00 | Inter Miami | 1.6 | 0–0 | 1.1 | Fire | 15,973 | DRV PNK Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-02-27 | 13:00 | Orlando City | 1.4 | 2–0 | 0.6 | CF Montréal | 21,283 | Exploria Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-02-27 | 14:00 | LA Galaxy | 1.6 | 1–0 | 1.0 | NYCFC | 25,174 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sun | 2022-02-27 | 15:00 | Atlanta Utd | 1.5 | 3–1 | 1.2 | Sporting KC | 67,523 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Sat | 2022-02-26 | 16:30 | Portland Timbers | 2.7 | 2–2 | 1.2 | NE Revolution | 23,411 | Providence Park | Chris Penso | Match Report | |
| Sun | 2022-02-27 | 17:00 | Seattle | 0.5 | 0–1 | 1.0 | Nashville | 30,013 | Lumen Field | Alex Chilowicz | Match Report | |
| Sun | 2022-02-27 | 18:00 | Dynamo FC | 0.5 | 0–0 | 0.4 | RSL | 18,561 | PNC Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-03-05 | 13:30 | NE Revolution | 1.7 | 1–0 | 1.0 | FC Dallas | 14,554 | Gillette Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-05 | 14:00 | Toronto FC | 0.7 | 1–4 | 2.3 | NY Red Bulls | 23,121 | BMO Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-03-05 | 14:30 | Sporting KC | 1.5 | 1–0 | 0.2 | Dynamo FC | 18,872 | Children's Mercy Park | Victor Rivas | Match Report | |
| Sat | 2022-03-05 | 14:30 | SJ Earthquakes | 1.3 | 3–3 | 1.9 | Crew | 12,888 | PayPal Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-05 | 15:00 | Vancouver W'caps | 0.5 | 0–0 | 1.9 | NYCFC | 18,643 | BC Place Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2022-03-05 | 16:00 | CF Montréal | 0.7 | 1–2 | 1.1 | Philadelphia | 13,067 | Stade Olympique | Drew Fischer | Match Report | |
| Sat | 2022-03-05 | 16:00 | Rapids | 1.6 | 3–0 | 1.1 | Atlanta Utd | 12,538 | Dick's Sporting Goods Park | Joe Dickerson | Match Report | |
| Sat | 2022-03-05 | 16:00 | RSL | 2.3 | 1–0 | 0.8 | Seattle | 20,017 | Rio Tinto Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-03-05 | 17:00 | Minnesota Utd | 1.9 | 1–1 | 1.7 | Nashville | 18,107 | Allianz Field | Armando Villarreal | Match Report | |
| Sat | 2022-03-05 | 17:00 | Fire | 0.5 | 0–0 | 0.2 | Orlando City | 25,477 | Soldier Field | Ismir Pekmic | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-03-05 | 18:00 | FC Cincinnati | 2.4 | 0–1 | 1.7 | D.C. United | 22,183 | TQL Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-03-06 | 15:00 | Austin | 1.9 | 5–1 | 0.7 | Inter Miami | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-05 | 19:30 | Charlotte | 0.5 | 0–1 | 2.1 | LA Galaxy | 74,479 | Bank of America Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-03-06 | 19:00 | LAFC | 2.2 | 1–1 | 0.6 | Portland Timbers | 22,102 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-03-12 | 12:30 | Seattle | 2.1 | 3–2 | 2.2 | LA Galaxy | 33,200 | Lumen Field | Allen Chapman | Match Report | |
| Sat | 2022-03-12 | 13:00 | NYCFC | 1.9 | 4–1 | 2.4 | CF Montréal | 21,113 | Yankee Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-03-12 | 13:30 | Crew | 1.5 | 2–1 | 0.9 | Toronto FC | 16,116 | Lower.com Field | Ismail Elfath | Match Report | |
| Sat | 2022-03-12 | 13:30 | Inter Miami | 0.4 | 0–2 | 0.5 | LAFC | 11,465 | DRV PNK Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-12 | 17:30 | Dynamo FC | 2.2 | 2–1 | 1.5 | Vancouver W'caps | 13,028 | PNC Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-03-13 | 16:30 | Atlanta Utd | 2.0 | 2–1 | 1.0 | Charlotte | 43,055 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-12 | 19:00 | Portland Timbers | 1.3 | 1–0 | 1.1 | Austin | 22,795 | Providence Park | Joe Dickerson | Match Report | |
| Sun | 2022-03-13 | 19:00 | NY Red Bulls | 2.3 | 0–1 | 0.7 | Minnesota Utd | 14,848 | Red Bull Arena | Lukasz Szpala | Match Report | |
| Sat | 2022-03-12 | 19:00 | Rapids | 2.4 | 2–0 | 0.8 | Sporting KC | 12,387 | Dick's Sporting Goods Park | Alex Chilowicz | Match Report | |
| Sat | 2022-03-12 | 19:30 | Orlando City | 1.4 | 1–2 | 1.2 | FC Cincinnati | 16,512 | Exploria Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-12 | 19:30 | NE Revolution | 1.2 | 2–3 | 2.2 | RSL | 10,633 | Gillette Stadium | Drew Fischer | Match Report | |
| Sat | 2022-03-12 | 19:30 | FC Dallas | 1.7 | 2–0 | 0.2 | Nashville | 13,448 | Toyota Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-03-12 | 19:30 | Philadelphia | 2.7 | 2–0 | 0.3 | SJ Earthquakes | 14,533 | Subaru Park | Victor Rivas | Match Report | |
| Sat | 2022-03-12 | 19:30 | D.C. United | 1.3 | 0–2 | 1.7 | Fire | 13,795 | Audi Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-03-19 | 12:30 | LA Galaxy | 2.3 | 0–1 | 0.5 | Orlando City | 25,174 | Dignity Health Sports Park | Alex Chilowicz | Match Report | |
| Sat | 2022-03-19 | 13:00 | NYCFC | 1.4 | 0–2 | 2.1 | Philadelphia | 15,968 | Yankee Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-19 | 13:00 | FC Cincinnati | 2.5 | 3–1 | 1.4 | Inter Miami | 19,365 | TQL Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-03-19 | 15:00 | Toronto FC | 1.4 | 2–1 | 1.1 | D.C. United | 21,501 | BMO Field | Ramy Touchan | Match Report | |
| Sat | 2022-03-19 | 16:00 | Atlanta Utd | 0.7 | 3–3 | 2.9 | CF Montréal | 42,578 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-19 | 17:00 | Fire | 1.7 | 3–1 | 0.5 | Sporting KC | 9,352 | Soldier Field | Tim Ford | Match Report | |
| Sat | 2022-03-19 | 19:00 | Charlotte | 1.3 | 3–1 | 1.8 | NE Revolution | 29,318 | Bank of America Stadium | Marcos de Oliveira | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-03-20 | 14:00 | NY Red Bulls | 1.4 | 1–1 | 2.7 | Crew | 15,323 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sun | 2022-03-20 | 15:30 | Austin | 2.0 | 1–1 | 1.7 | Seattle | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-03-19 | 19:00 | Minnesota Utd | 1.8 | 1–0 | 0.3 | SJ Earthquakes | 18,685 | Allianz Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-03-19 | 19:30 | Dynamo FC | 1.1 | 1–1 | 1.2 | Rapids | 17,007 | PNC Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-03-19 | 19:30 | FC Dallas | 1.6 | 4–1 | 0.8 | Portland Timbers | 19,096 | Toyota Stadium | Allen Chapman | Match Report | |
| Sat | 2022-03-19 | 19:30 | RSL | 0.9 | 2–1 | 2.3 | Nashville | 20,036 | Rio Tinto Stadium | Tori Penso | Match Report | |
| Sun | 2022-03-20 | 19:00 | LAFC | 1.7 | 3–1 | 1.1 | Vancouver W'caps | 22,065 | Banc of California Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-26 | 17:00 | Charlotte | 1.0 | 2–0 | 1.6 | FC Cincinnati | 30,242 | Bank of America Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-03-26 | 18:00 | Sporting KC | 1.0 | 1–0 | 1.0 | RSL | 19,107 | Children's Mercy Park | Joe Dickerson | Match Report | |
| Sun | 2022-03-27 | 13:00 | Portland Timbers | 1.9 | 1–1 | 0.8 | Orlando City | 22,948 | Providence Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-04-02 | 14:30 | Fire | 0.7 | 0–0 | 0.3 | FC Dallas | 11,411 | Soldier Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-04-02 | 16:00 | Toronto FC | 0.9 | 2–1 | 1.1 | NYCFC | 21,802 | BMO Field | Drew Fischer | Match Report | |
| Sat | 2022-04-02 | 16:00 | FC Cincinnati | 2.6 | 3–4 | 1.7 | CF Montréal | 20,386 | TQL Stadium | Tori Penso | Match Report | |
| Sat | 2022-04-02 | 16:30 | SJ Earthquakes | 2.9 | 2–2 | 2.3 | Austin | 13,062 | PayPal Park | Alex Chilowicz | Match Report | |
| Sat | 2022-04-02 | 18:00 | Crew | 1.7 | 0–1 | 0.9 | Nashville | 20,371 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-02 | 19:30 | NE Revolution | 1.1 | 0–1 | 0.8 | NY Red Bulls | 16,265 | Gillette Stadium | Victor Rivas | Match Report | |
| Sat | 2022-04-02 | 19:30 | Philadelphia | 1.0 | 2–0 | 0.6 | Charlotte | 18,136 | Subaru Park | Tim Ford | Match Report | |
| Sat | 2022-04-02 | 19:30 | Orlando City | 1.4 | 2–4 | 2.7 | LAFC | 16,753 | Exploria Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-04-02 | 19:30 | D.C. United | 0.5 | 0–1 | 1.0 | Atlanta Utd | 17,289 | Audi Field | Armando Villarreal | Match Report | |
| Sun | 2022-04-03 | 13:30 | Portland Timbers | 1.1 | 1–3 | 1.5 | LA Galaxy | 24,534 | Providence Park | Nima Saghafi | Match Report | |
| Sat | 2022-04-02 | 17:00 | Vancouver W'caps | 1.0 | 1–0 | 0.6 | Sporting KC | 16,772 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-04-02 | 19:00 | Minnesota Utd | 2.1 | 1–2 | 1.5 | Seattle | 19,615 | Allianz Field | Ismail Elfath | Match Report | |
| Sat | 2022-04-02 | 19:00 | Rapids | 1.7 | 1–1 | 1.1 | RSL | 13,380 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2022-04-02 | 20:00 | Inter Miami | 1.8 | 1–3 | 2.5 | Dynamo FC | 13,083 | DRV PNK Stadium | Allen Chapman | Match Report | |
| Sat | 2022-04-09 | 13:00 | Orlando City | 3.4 | 1–0 | 0.5 | Fire | 16,051 | Exploria Stadium | Victor Rivas | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-09 | 15:00 | Inter Miami | 1.3 | 3–2 | 1.2 | NE Revolution | 11,472 | DRV PNK Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-04-09 | 16:00 | NY Red Bulls | 1.4 | 1–2 | 1.7 | CF Montréal | 15,734 | Red Bull Arena | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-04-09 | 16:30 | LA Galaxy | 1.0 | 2–1 | 2.0 | LAFC | 25,174 | Dignity Health Sports Park | Chris Penso | Match Report | |
| Sat | 2022-04-09 | 18:00 | Philadelphia | 1.8 | 1–0 | 1.4 | Crew | 18,321 | Subaru Park | Armando Villarreal | Match Report | |
| Sun | 2022-04-10 | 13:30 | Charlotte | 0.9 | 1–0 | 1.3 | Atlanta Utd | 32,496 | Bank of America Stadium | Allen Chapman | Match Report | |
| Sat | 2022-04-09 | 18:00 | RSL | 1.3 | 2–2 | 0.9 | Toronto FC | 20,136 | Rio Tinto Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-04-10 | 18:30 | Austin | 1.2 | 1–0 | 0.5 | Minnesota Utd | 20,738 | Q2 Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-09 | 19:00 | Vancouver W'caps | 2.5 | 2–3 | 1.3 | Portland Timbers | 16,772 | BC Place Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-04-09 | 19:30 | Dynamo FC | 1.4 | 4–3 | 1.4 | SJ Earthquakes | 15,414 | PNC Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-04-09 | 19:30 | Sporting KC | 1.2 | 1–2 | 2.8 | Nashville | 18,852 | Children's Mercy Park | Ismail Elfath | Match Report | |
| Sat | 2022-04-09 | 19:30 | FC Dallas | 1.4 | 3–1 | 2.1 | Rapids | 15,893 | Toyota Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-04-16 | 12:30 | SJ Earthquakes | 1.3 | 2–2 | 1.8 | Nashville | 10,394 | PayPal Park | Tim Ford | Match Report | |
| Sat | 2022-04-16 | 15:00 | CF Montréal | 1.5 | 2–1 | 0.3 | Vancouver W'caps | 12,042 | Stade Saputo | Nima Saghafi | Match Report | |
| Sat | 2022-04-16 | 17:00 | Dynamo FC | 1.5 | 0–0 | 1.5 | Portland Timbers | 13,650 | PNC Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-16 | 18:00 | Atlanta Utd | 2.8 | 0–0 | 1.3 | FC Cincinnati | 42,948 | Mercedes-Benz Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-16 | 19:00 | NY Red Bulls | 1.6 | 0–0 | 0.5 | FC Dallas | 14,456 | Red Bull Arena | Fotis Bazakos | Match Report | |
| Sat | 2022-04-16 | 19:30 | D.C. United | 1.5 | 2–3 | 2.8 | Austin | 16,840 | Audi Field | Tori Penso | Match Report | |
| Sat | 2022-04-16 | 19:30 | Toronto FC | 0.4 | 2–1 | 1.7 | Philadelphia | 20,809 | BMO Field | Alex Chilowicz | Match Report | |
| Sat | 2022-04-16 | 19:30 | Crew | 1.3 | 0–2 | 1.3 | Orlando City | 18,030 | Lower.com Field | Drew Fischer | Match Report | |
| Sat | 2022-04-16 | 19:30 | NE Revolution | 1.3 | 2–1 | 0.5 | Charlotte | 15,344 | Gillette Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-04-17 | 13:00 | LAFC | 2.0 | 3–1 | 1.0 | Sporting KC | 22,097 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-04-17 | 13:00 | NYCFC | 3.3 | 6–0 | 1.2 | RSL | 14,513 | Yankee Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-04-16 | 19:00 | Seattle | 1.1 | 0–1 | 0.7 | Inter Miami | 32,126 | Lumen Field | Joe Dickerson | Match Report | |
| Sat | 2022-04-16 | 19:00 | Minnesota Utd | 1.9 | 3–1 | 2.0 | Rapids | 19,629 | Allianz Field | Chris Penso | Match Report | |
| Sat | 2022-04-16 | 19:00 | Fire | 0.4 | 0–0 | 0.4 | LA Galaxy | 30,282 | Soldier Field | Ted Unkel | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-23 | 14:00 | FC Dallas | 2.2 | 2–1 | 1.0 | Dynamo FC | 15,792 | Toyota Stadium | Victor Rivas | Match Report | |
| Sat | 2022-04-23 | 15:00 | Philadelphia | 1.2 | 1–1 | 0.5 | CF Montréal | 18,476 | Subaru Park | Lukasz Szpala | Match Report | |
| Sat | 2022-04-23 | 16:00 | Minnesota Utd | 0.9 | 3–0 | 1.0 | Fire | 19,658 | Allianz Field | Silviu Petrescu | Match Report | |
| Sat | 2022-04-23 | 19:30 | D.C. United | 1.5 | 3–2 | 2.0 | NE Revolution | 17,131 | Audi Field | Marcos de Oliveira | Match Report | |
| Sun | 2022-04-24 | 13:00 | Inter Miami | 1.9 | 2–1 | 2.1 | Atlanta Utd | 13,433 | DRV PNK Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-04-24 | 15:30 | Orlando City | 0.1 | 0–3 | 2.3 | NY Red Bulls | 17,503 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sun | 2022-04-24 | 17:00 | FC Cincinnati | 1.5 | 1–2 | 1.8 | LAFC | 20,883 | TQL Stadium | Ismail Elfath | Match Report | |
| Sun | 2022-04-24 | 17:00 | NYCFC | 4.2 | 5–4 | 1.2 | Toronto FC | 17,626 | Citi Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-23 | 19:00 | Rapids | 0.6 | 0–0 | 1.2 | Charlotte | 13,160 | Dick's Sporting Goods Park | Ismir Pekmic | Match Report | |
| Sat | 2022-04-23 | 19:00 | SJ Earthquakes | 2.7 | 4–3 | 2.5 | Seattle | 12,467 | PayPal Park | Ted Unkel | Match Report | |
| Sat | 2022-04-23 | 19:00 | Portland Timbers | 0.5 | 0–0 | 0.9 | RSL | 24,206 | Providence Park | Chris Penso | Match Report | |
| Sat | 2022-04-23 | 19:30 | Austin | 0.9 | 3–0 | 0.7 | Vancouver W'caps | 20,738 | Q2 Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-04-23 | 19:30 | LA Galaxy | 0.9 | 1–0 | 0.4 | Nashville | 26,674 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Sat | 2022-04-23 | 19:30 | Sporting KC | 0.3 | 0–0 | 0.7 | Crew | 18,483 | Children's Mercy Park | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-30 | 12:30 | Dynamo FC | 1.8 | 1–2 | 0.7 | Austin | 16,296 | PNC Stadium | Ted Unkel | Match Report | |
| Sat | 2022-04-30 | 13:30 | RSL | 0.6 | 1–0 | 1.0 | LA Galaxy | 20,775 | Rio Tinto Stadium | Drew Fischer | Match Report | |
| Sat | 2022-04-30 | 15:00 | Toronto FC | 1.0 | 1–2 | 0.8 | FC Cincinnati | 23,591 | BMO Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-04-30 | 16:00 | CF Montréal | 1.9 | 2–1 | 0.8 | Atlanta Utd | 15,060 | Stade Saputo | Alex Chilowicz | Match Report | |
| Sat | 2022-04-30 | 19:30 | NE Revolution | 1.8 | 2–0 | 0.5 | Inter Miami | 25,509 | Gillette Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-04-30 | 19:30 | Crew | 1.5 | 3–0 | 1.4 | D.C. United | 19,402 | Lower.com Field | Tim Ford | Match Report | |
| Sat | 2022-04-30 | 19:30 | Orlando City | 1.5 | 2–1 | 1.2 | Charlotte | 17,012 | Exploria Stadium | Fotis Bazakos | Match Report | |
| Sun | 2022-05-01 | 13:00 | NYCFC | 3.3 | 3–0 | 0.4 | SJ Earthquakes | 17,174 | Yankee Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-05-01 | 15:00 | Nashville | 2.0 | 1–1 | 1.1 | Philadelphia | 30,109 | Geodis Park | Chris Penso | Match Report | |
| Sat | 2022-04-30 | 19:00 | Fire | 1.3 | 1–2 | 2.0 | NY Red Bulls | 11,108 | Soldier Field | Jon Freemon | Match Report | |
| Sat | 2022-04-30 | 19:00 | Rapids | 1.6 | 2–0 | 1.0 | Portland Timbers | 14,038 | Dick's Sporting Goods Park | Armando Villarreal | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-30 | 19:30 | Sporting KC | 1.8 | 2–2 | 1.0 | FC Dallas | 17,334 | Children's Mercy Park | Nima Saghafi | Match Report | |
| Sun | 2022-05-01 | 19:00 | LAFC | 2.3 | 2–0 | 0.7 | Minnesota Utd | 22,010 | Banc of California Stadium | Allen Chapman | Match Report | |
| Wed | 2022-05-04 | 19:30 | FC Cincinnati | 4.4 | 2–0 | 0.5 | Toronto FC | 19,563 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-05-07 | 15:30 | Charlotte | 1.7 | 1–0 | 1.2 | Inter Miami | 32,018 | Bank of America Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2022-05-07 | 16:00 | CF Montréal | 3.3 | 4–1 | 0.2 | Orlando City | 14,068 | Stade Saputo | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-05-07 | 18:00 | Atlanta Utd | 2.5 | 4–1 | 1.8 | Fire | 42,547 | Mercedes-Benz Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-05-07 | 19:00 | NYCFC | 1.4 | 0–0 | 0.3 | Sporting KC | 15,031 | Citi Field | Tim Ford | Match Report | |
| Sat | 2022-05-07 | 19:00 | NY Red Bulls | 1.2 | 1–1 | 0.5 | Portland Timbers | 17,107 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sat | 2022-05-07 | 19:30 | D.C. United | 0.9 | 2–0 | 0.7 | Dynamo FC | 15,194 | Audi Field | Jon Freemon | Match Report | |
| Sat | 2022-05-07 | 19:30 | NE Revolution | 1.0 | 2–2 | 1.1 | Crew | 26,421 | Gillette Stadium | Nima Saghafi | Match Report | |
| Sun | 2022-05-08 | 13:00 | Vancouver W'caps | 2.3 | 1–0 | 1.8 | Toronto FC | 17,709 | BC Place Stadium | Victor Rivas | Match Report | |
| Sun | 2022-05-08 | 16:00 | Nashville | 2.4 | 2–0 | 0.3 | RSL | 28,226 | Geodis Park | Fotis Bazakos | Match Report | |
| Sun | 2022-05-08 | 18:00 | Austin | 1.2 | 0–1 | 1.3 | LA Galaxy | 20,738 | Q2 Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-05-07 | 19:00 | Minnesota Utd | 1.0 | 0–1 | 2.0 | FC Cincinnati | 19,662 | Allianz Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-05-07 | 19:00 | SJ Earthquakes | 1.1 | 1–0 | 0.8 | Rapids | 14,077 | PayPal Park | Tori Penso | Match Report | |
| Sat | 2022-05-07 | 19:30 | FC Dallas | 2.6 | 2–0 | 0.7 | Seattle | 19,096 | Toyota Stadium | Allen Chapman | Match Report | |
| Sat | 2022-05-07 | 20:00 | LAFC | 1.4 | 2–2 | 1.1 | Philadelphia | 22,022 | Banc of California Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-05-14 | 15:00 | Toronto FC | 0.7 | 0–1 | 1.5 | Orlando City | 26,146 | BMO Field | Nima Saghafi | Match Report | |
| Sat | 2022-05-14 | 15:30 | Rapids | 3.1 | 2–0 | 1.3 | LAFC | 15,022 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2022-05-14 | 16:00 | Vancouver W'caps | 1.3 | 3–3 | 1.7 | SJ Earthquakes | 15,087 | BC Place Stadium | Tim Ford | Match Report | |
| Sat | 2022-05-14 | 19:00 | NYCFC | 2.6 | 2–0 | 0.5 | Crew | 18,813 | Yankee Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2022-05-14 | 19:00 | Charlotte | 1.3 | 0–2 | 1.8 | CF Montréal | 33,323 | Bank of America Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-05-14 | 19:30 | Philadelphia | 2.5 | 1–1 | 1.1 | NY Red Bulls | 18,579 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sun | 2022-05-15 | 13:00 | Seattle | 2.8 | 3–1 | 1.5 | Minnesota Utd | 32,613 | Lumen Field | Joe Dickerson | Match Report | |
| Sun | 2022-05-15 | 13:30 | Atlanta Utd | 2.2 | 2–2 | 1.3 | NE Revolution | 42,516 | Mercedes-Benz Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-05-14 | 19:00 | Fire | 1.5 | 1–2 | 0.9 | FC Cincinnati | 14,049 | Soldier Field | Tori Penso | Match Report | |
| Sat | 2022-05-14 | 19:00 | Portland Timbers | 3.1 | 7–2 | 1.7 | Sporting KC | 23,503 | Providence Park | Victor Rivas | Match Report | |
| Sat | 2022-05-14 | 19:30 | LA Galaxy | 1.6 | 1–3 | 3.1 | FC Dallas | 25,174 | Dignity Health Sports Park | Chris Penso | Match Report | |
| Sat | 2022-05-14 | 19:30 | RSL | 1.8 | 2–1 | 0.9 | Austin | 20,122 | Rio Tinto Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-05-14 | 19:30 | Dynamo FC | 1.7 | 2–0 | 1.4 | Nashville | 16,035 | PNC Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-05-14 | 20:00 | Inter Miami | 0.8 | 2–2 | 1.1 | D.C. United | 13,317 | DRV PNK Stadium | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-05-18 | 19:30 | Philadelphia | 1.6 | 0–0 | 0.9 | Inter Miami | 15,747 | Subaru Park | Fotis Bazakos | Match Report | |
| Wed | 2022-05-18 | 19:30 | NY Red Bulls | 2.2 | 3–3 | 1.7 | Fire | 13,257 | Red Bull Arena | Ted Unkel | Match Report | |
| Wed | 2022-05-18 | 19:30 | D.C. United | 0.6 | 0–2 | 1.5 | NYCFC | 16,072 | Audi Field | Chris Penso | Match Report | |
| Wed | 2022-05-18 | 19:00 | Minnesota Utd | 2.7 | 1–1 | 2.4 | LA Galaxy | 19,645 | Allianz Field | Jair Marrufo | Match Report | |
| Wed | 2022-05-18 | 19:00 | Vancouver W'caps | 1.2 | 2–1 | 1.0 | FC Dallas | 12,716 | BC Place Stadium | Ismir Pekmic | Match Report | |
| Wed | 2022-05-18 | 19:30 | SJ Earthquakes | 2.0 | 3–2 | 1.1 | Portland Timbers | 11,788 | PayPal Park | Lukasz Szpala | Match Report | |
| Wed | 2022-05-18 | 19:30 | Nashville | 0.6 | 2–1 | 0.8 | CF Montréal | 26,003 | Geodis Park | Jon Freemon | Match Report | |
| Wed | 2022-05-18 | 19:30 | Dynamo FC | 1.2 | 0–1 | 1.3 | Seattle | 11,093 | PNC Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2022-05-18 | 19:30 | Sporting KC | 0.5 | 2–1 | 1.3 | Rapids | 17,233 | Children's Mercy Park | Drew Fischer | Match Report | |
| Wed | 2022-05-18 | 19:30 | LAFC | 1.9 | 1–2 | 0.7 | Austin | 22,034 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-05-21 | 15:30 | Crew | 0.9 | 0–2 | 1.8 | LAFC | 19,649 | Lower.com Field | Victor Rivas | Match Report | |
| Sat | 2022-05-21 | 18:00 | FC Cincinnati | 0.9 | 2–3 | 0.8 | NE Revolution | 22,844 | TQL Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-05-21 | 18:30 | Nashville | 1.5 | 2–2 | 1.9 | Atlanta Utd | 30,109 | Geodis Park | Ted Unkel | Match Report | |
| Sat | 2022-05-21 | 18:30 | D.C. United | 3.0 | 2–2 | 2.0 | Toronto FC | 18,320 | Audi Field | Ismir Pekmic | Match Report | |
| Sun | 2022-05-22 | 16:00 | CF Montréal | 0.6 | 1–2 | 2.0 | RSL | 14,205 | Stade Saputo | Ramy Touchan | Match Report | |
| Sun | 2022-05-22 | 16:30 | SJ Earthquakes | 1.0 | 1–1 | 1.3 | Sporting KC | 14,233 | PayPal Park | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-05-22 | 17:00 | Charlotte | 1.9 | 2–1 | 1.0 | Vancouver W'caps | 32,034 | Bank of America Stadium | Nima Saghafi | Match Report | |
| Sun | 2022-05-22 | 17:00 | NYCFC | 2.0 | 1–0 | 1.3 | Fire | 18,823 | Yankee Stadium | Fotis Bazakos | Match Report | |
| Sun | 2022-05-22 | 18:00 | Inter Miami | 1.9 | 2–0 | 1.3 | NY Red Bulls | 11,007 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-05-22 | 18:00 | FC Dallas | 1.3 | 1–2 | 0.8 | Minnesota Utd | 15,280 | Toyota Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-05-22 | 17:00 | LA Galaxy | 1.3 | 0–3 | 1.5 | Dynamo FC | 22,471 | Dignity Health Sports Park | Marcos de Oliveira | Match Report | |
| Sun | 2022-05-22 | 18:00 | Rapids | 1.7 | 1–0 | 0.7 | Seattle | 14,923 | Dick's Sporting Goods Park | Tim Ford | Match Report | |
| Sun | 2022-05-22 | 19:00 | Portland Timbers | 0.8 | 0–2 | 1.1 | Philadelphia | 22,288 | Providence Park | Allen Chapman | Match Report | |
| Sun | 2022-05-22 | 19:00 | Austin | 3.1 | 2–2 | 1.8 | Orlando City | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-05-28 | 15:00 | LAFC | 2.1 | 3–2 | 1.9 | SJ Earthquakes | 22,007 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-05-28 | 19:00 | NY Red Bulls | 1.0 | 4–1 | 0.7 | D.C. United | 13,678 | Red Bull Arena | Allen Chapman | Match Report | |
| Sat | 2022-05-28 | 19:00 | Atlanta Utd | 2.0 | 1–2 | 0.8 | Crew | 42,504 | Mercedes-Benz Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-05-28 | 19:00 | Toronto FC | 1.1 | 3–2 | 3.2 | Fire | 25,906 | BMO Field | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-05-28 | 19:30 | CF Montréal | 2.8 | 4–3 | 0.9 | FC Cincinnati | 14,225 | Stade Saputo | Fotis Bazakos | Match Report | |
| Sat | 2022-05-28 | 19:30 | NE Revolution | 2.9 | 1–1 | 0.7 | Philadelphia | 20,398 | Gillette Stadium | Jon Freemon | Match Report | |
| Sat | 2022-05-28 | 19:30 | Orlando City | 1.2 | 1–3 | 1.5 | FC Dallas | 17,380 | Exploria Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-05-29 | 15:00 | LA Galaxy | 3.6 | 4–1 | 0.9 | Austin | 20,433 | Dignity Health Sports Park | Rubiel Vazquez | Match Report | |
| Sat | 2022-05-28 | 19:00 | Minnesota Utd | 1.1 | 0–1 | 0.6 | NYCFC | 19,695 | Allianz Field | Michael Radchuk | Match Report | |
| Sat | 2022-05-28 | 19:00 | Rapids | 0.9 | 1–3 | 1.7 | Nashville | 15,465 | Dick's Sporting Goods Park | Nima Saghafi | Match Report | |
| Sat | 2022-05-28 | 19:30 | RSL | 2.7 | 3–0 | 1.1 | Dynamo FC | 20,489 | Rio Tinto Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-05-28 | 20:00 | Sporting KC | 1.1 | 0–1 | 1.3 | Vancouver W'caps | 19,206 | Children's Mercy Park | Ted Unkel | Match Report | |
| Sat | 2022-05-28 | 20:00 | Inter Miami | 1.8 | 2–1 | 1.3 | Portland Timbers | 11,161 | DRV PNK Stadium | Chris Penso | Match Report | |
| Sun | 2022-05-29 | 18:30 | Seattle | 1.4 | 2–1 | 1.0 | Charlotte | 32,763 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2022-06-04 | 16:00 | Vancouver W'caps | 1.4 | 2–1 | 0.8 | RSL | 17,134 | BC Place Stadium | Jon Freemon | Match Report | |
| Sat | 2022-06-11 | 15:00 | Charlotte | 2.1 | 2–0 | 0.6 | NY Red Bulls | 32,064 | Bank of America Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-06-12 | 14:00 | Sporting KC | 1.0 | 1–2 | 1.3 | NE Revolution | 18,703 | Children's Mercy Park | Chris Penso | Match Report | |
| Sat | 2022-06-11 | 19:00 | Nashville | 1.3 | 0–0 | 0.6 | SJ Earthquakes | 28,672 | Geodis Park | Allen Chapman | Match Report | |
| Tue | 2022-06-14 | 19:30 | Seattle | 2.5 | 4–0 | 0.9 | Vancouver W'caps | 31,165 | Lumen Field | Lukasz Szpala | Match Report | |
| Wed | 2022-06-15 | 19:30 | NE Revolution | 1.1 | 1–1 | 0.8 | Orlando City | 15,308 | Gillette Stadium | Ramy Touchan | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-18 | 12:00 | Seattle | 1.2 | 1–1 | 1.3 | LAFC | 34,642 | Lumen Field | Allen Chapman | Match Report | |
| Sat | 2022-06-18 | 14:00 | LA Galaxy | 1.5 | 1–1 | 0.9 | Portland Timbers | 21,414 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sat | 2022-06-18 | 19:00 | NY Red Bulls | 1.7 | 2–0 | 1.4 | Toronto FC | 19,142 | Red Bull Arena | Ramy Touchan | Match Report | |
| Sat | 2022-06-18 | 19:30 | Crew | 1.1 | 1–1 | 0.7 | Charlotte | 20,446 | Lower.com Field | Silviu Petrescu | Match Report | |
| Sat | 2022-06-18 | 19:30 | Philadelphia | 1.3 | 1–1 | 1.0 | FC Cincinnati | 18,717 | Subaru Park | Tim Ford | Match Report | |
| Sat | 2022-06-18 | 19:30 | CF Montréal | 1.4 | 0–1 | 1.5 | Austin | 15,045 | Stade Saputo | Ted Unkel | Match Report | |
| Sat | 2022-06-18 | 19:30 | Orlando City | 3.0 | 2–1 | 0.7 | Dynamo FC | 16,333 | Exploria Stadium | Rosendo Mendoza | Match Report | |
| Sun | 2022-06-19 | 15:00 | Atlanta Utd | 2.1 | 2–0 | 0.9 | Inter Miami | 42,539 | Mercedes-Benz Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-06-19 | 17:00 | NYCFC | 1.3 | 1–1 | 0.3 | Rapids | 19,812 | Yankee Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-06-19 | 17:00 | Nashville | 0.9 | 1–2 | 0.4 | Sporting KC | 29,269 | Geodis Park | Victor Rivas | Match Report | |
| Sun | 2022-06-19 | 17:00 | NE Revolution | 0.5 | 2–1 | 1.3 | Minnesota Utd | 21,289 | Gillette Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-06-18 | 19:00 | Fire | 1.3 | 1–0 | 0.9 | D.C. United | 17,650 | Soldier Field | Nima Saghafi | Match Report | |
| Sat | 2022-06-18 | 19:30 | RSL | 2.6 | 2–0 | 0.6 | SJ Earthquakes | 20,517 | Rio Tinto Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-06-18 | 20:00 | FC Dallas | 1.0 | 0–2 | 0.5 | Vancouver W'caps | 19,096 | Toyota Stadium | Tori Penso | Match Report | |
| Fri | 2022-06-24 | 19:30 | FC Cincinnati | 1.2 | 1–0 | 0.3 | Orlando City | 24,263 | TQL Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-06-25 | 12:00 | Seattle | 2.6 | 3–0 | 0.6 | Sporting KC | 33,380 | Lumen Field | Alex Chilowicz | Match Report | |
| Sat | 2022-06-25 | 17:00 | D.C. United | 0.8 | 1–3 | 1.1 | Nashville | 19,325 | Audi Field | Lukasz Szpala | Match Report | |
| Sat | 2022-06-25 | 19:30 | CF Montréal | 0.8 | 2–1 | 1.2 | Charlotte | 13,520 | Stade Saputo | Nima Saghafi | Match Report | |
| Sat | 2022-06-25 | 19:30 | Toronto FC | 2.0 | 2–1 | 1.4 | Atlanta Utd | 25,527 | BMO Field | Jon Freemon | Match Report | |
| Sun | 2022-06-26 | 12:00 | LAFC | 1.7 | 2–0 | 0.6 | NY Red Bulls | Banc of California Stadium | Joe Dickerson | Match Report | ||
| Sun | 2022-06-26 | 18:00 | Philadelphia | 1.8 | 2–1 | 1.4 | NYCFC | 18,589 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2022-06-25 | 19:00 | Dynamo FC | 1.6 | 2–0 | 2.0 | Fire | 13,081 | PNC Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-06-25 | 19:30 | Portland Timbers | 3.1 | 3–0 | 1.5 | Rapids | 23,448 | Providence Park | Rosendo Mendoza | Match Report | |
| Sat | 2022-06-25 | 20:00 | Inter Miami | 1.6 | 2–1 | 0.8 | Minnesota Utd | 12,147 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sat | 2022-06-25 | 20:00 | Austin | 1.6 | 2–2 | 2.0 | FC Dallas | 20,738 | Q2 Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-25 | 20:00 | RSL | 0.7 | 0–0 | 0.5 | Crew | 20,311 | Rio Tinto Stadium | Mark Allatin | Match Report | |
| Sun | 2022-06-26 | 17:00 | Vancouver W'caps | 1.2 | 0–0 | 1.2 | NE Revolution | 15,084 | BC Place Stadium | Filip Dujic | Match Report | |
| Wed | 2022-06-29 | 19:30 | Toronto FC | 1.7 | 1–2 | 0.8 | Crew | 21,289 | BMO Field | Armando Villarreal | Match Report | |
| Wed | 2022-06-29 | 19:30 | FC Cincinnati | 2.2 | 4–4 | 2.7 | NYCFC | 21,258 | TQL Stadium | Ismir Pekmic | Match Report | |
| Thu | 2022-06-30 | 19:00 | Charlotte | 0.5 | 0–1 | 0.4 | Austin | 31,661 | Bank of America Stadium | Tim Ford | Match Report | |
| Wed | 2022-06-29 | 19:00 | Fire | 0.7 | 1–0 | 0.5 | Philadelphia | 10,384 | Soldier Field | Michael Radchuk | Match Report | |
| Wed | 2022-06-29 | 19:00 | Seattle | 0.9 | 1–2 | 1.4 | CF Montréal | 32,375 | Lumen Field | Joe Dickerson | Match Report | |
| Wed | 2022-06-29 | 19:30 | LAFC | 1.9 | 3–1 | 0.6 | FC Dallas | 22,014 | Banc of California Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-06-29 | 19:30 | Portland Timbers | 1.4 | 2–1 | 2.2 | Dynamo FC | 22,932 | Providence Park | Lukasz Szpala | Match Report | |
| Wed | 2022-06-29 | 19:30 | LA Galaxy | 2.4 | 2–3 | 1.2 | Minnesota Utd | 18,337 | Dignity Health Sports Park | Ted Unkel | Match Report | |
| Thu | 2022-06-30 | 20:00 | NY Red Bulls | 1.8 | 2–1 | 1.3 | Atlanta Utd | 14,122 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Sat | 2022-07-02 | 19:30 | Toronto FC | 1.2 | 0–2 | 1.9 | Seattle | 23,594 | BMO Field | Silviu Petrescu | Match Report | |
| Sun | 2022-07-03 | 17:00 | NYCFC | 2.2 | 2–2 | 1.5 | Atlanta Utd | 17,704 | Yankee Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-07-02 | 19:00 | Vancouver W'caps | 0.9 | 1–0 | 0.4 | LAFC | 18,292 | BC Place Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-07-03 | 19:30 | NE Revolution | 1.5 | 2–2 | 1.5 | FC Cincinnati | 20,193 | Gillette Stadium | Jon Freemon | Match Report | |
| Sun | 2022-07-03 | 19:30 | Crew | 1.3 | 0–0 | 0.3 | Philadelphia | 20,469 | Lower.com Field | Nima Saghafi | Match Report | |
| Sun | 2022-07-03 | 18:00 | SJ Earthquakes | 2.5 | 2–1 | 1.6 | Fire | 13,224 | PayPal Park | Victor Rivas | Match Report | |
| Sun | 2022-07-03 | 19:00 | Minnesota Utd | 2.7 | 3–2 | 1.5 | RSL | Allianz Field | Ramy Touchan | Match Report | ||
| Sun | 2022-07-03 | 19:00 | Sporting KC | 0.6 | 0–1 | 0.6 | NY Red Bulls | 19,065 | Children's Mercy Park | Marcos de Oliveira | Match Report | |
| Mon | 2022-07-04 | 19:00 | Orlando City | 2.4 | 3–5 | 1.4 | D.C. United | 16 | Exploria Stadium | Allen Chapman | Match Report | |
| Sun | 2022-07-03 | 19:30 | Dynamo FC | 1.1 | 1–2 | 1.7 | Charlotte | 19,242 | PNC Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-07-03 | 19:30 | Nashville | 1.2 | 2–2 | 1.9 | Portland Timbers | 28,387 | Geodis Park | Armando Villarreal | Match Report | |
| Mon | 2022-07-04 | 19:00 | Rapids | 1.8 | 2–3 | 1.8 | Austin | 18,084 | Dick's Sporting Goods Park | Joe Dickerson | Match Report | |
| Mon | 2022-07-04 | 19:30 | LA Galaxy | 3.2 | 4–0 | 0.9 | CF Montréal | 23,855 | Dignity Health Sports Park | Tim Ford | Match Report | |
| Mon | 2022-07-04 | 20:00 | FC Dallas | 1.1 | 1–1 | 2.6 | Inter Miami | 19,096 | Toyota Stadium | Alex Chilowicz | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Fri | 2022-07-08 | 19:30 | Philadelphia | 5.6 | 7–0 | 0.7 | D.C. United | 19,007 | Subaru Park | Ted Unkel | Match Report | |
| Sat | 2022-07-09 | 13:00 | NYCFC | 5.3 | 4–2 | 1.6 | NE Revolution | 17,991 | Yankee Stadium | Tim Ford | Match Report | |
| Sat | 2022-07-09 | 13:30 | Seattle | 1.4 | 0–3 | 2.8 | Portland Timbers | 47,722 | Lumen Field | Chris Penso | Match Report | |
| Sat | 2022-07-09 | 19:00 | Atlanta Utd | 1.2 | 0–3 | 2.4 | Austin | 67,516 | Mercedes-Benz Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-07-09 | 19:00 | Charlotte | 2.1 | 4–1 | 2.4 | Nashville | 36,244 | Bank of America Stadium | Joe Dickerson | Match Report | |
| Fri | 2022-07-08 | 19:00 | LAFC | 1.5 | 3–2 | 1.7 | LA Galaxy | 22,231 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-07-09 | 19:30 | FC Cincinnati | 1.5 | 1–1 | 1.2 | NY Red Bulls | 24,476 | TQL Stadium | Rosendo Mendoza | Match Report | |
| Fri | 2022-07-08 | 19:30 | Vancouver W'caps | 0.7 | 1–3 | 0.9 | Minnesota Utd | 14,201 | BC Place Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-07-09 | 19:30 | CF Montréal | 1.9 | 1–2 | 0.5 | Sporting KC | 14,127 | Stade Saputo | Ismir Pekmic | Match Report | |
| Sat | 2022-07-09 | 19:30 | Toronto FC | 1.8 | 2–2 | 1.3 | SJ Earthquakes | 27,149 | BMO Field | Fotis Bazakos | Match Report | |
| Sat | 2022-07-09 | 19:00 | Fire | 2.1 | 2–3 | 1.7 | Crew | 15,157 | Soldier Field | Ramy Touchan | Match Report | |
| Sat | 2022-07-09 | 19:30 | Dynamo FC | 2.5 | 2–2 | 1.4 | FC Dallas | 21,284 | PNC Stadium | Jon Freemon | Match Report | |
| Sat | 2022-07-09 | 20:00 | RSL | 1.3 | 2–2 | 2.9 | Rapids | 20,242 | Rio Tinto Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-07-09 | 22:00 | Orlando City | 0.9 | 1–0 | 0.8 | Inter Miami | 20,052 | Exploria Stadium | Nima Saghafi | Match Report | |
| Wed | 2022-07-13 | 19:30 | Atlanta Utd | 1.3 | 2–1 | 0.8 | RSL | 42,509 | Mercedes-Benz Stadium | Drew Fischer | Match Report | |
| Tue | 2022-07-12 | 20:00 | Austin | 2.1 | 3–1 | 0.7 | Dynamo FC | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Wed | 2022-07-13 | 19:00 | Minnesota Utd | 1.1 | 1–1 | 0.9 | Sporting KC | 19,657 | Allianz Field | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-07-13 | 19:00 | LA Galaxy | 2.2 | 2–3 | 1.7 | SJ Earthquakes | 18,453 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Wed | 2022-07-13 | 19:00 | Fire | 1.3 | 2–0 | 0.4 | Toronto FC | 10,450 | Soldier Field | Lukasz Szpala | Match Report | |
| Wed | 2022-07-13 | 19:00 | Rapids | 2.4 | 1–1 | 0.7 | Orlando City | 12,538 | Dick's Sporting Goods Park | Fotis Bazakos | Match Report | |
| Wed | 2022-07-13 | 19:30 | Nashville | 1.3 | 1–0 | 0.8 | Seattle | 26,927 | Geodis Park | Rubiel Vazquez | Match Report | |
| Wed | 2022-07-13 | 20:00 | FC Cincinnati | 1.7 | 2–2 | 1.6 | Vancouver W'caps | 21,078 | TQL Stadium | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-07-13 | 20:00 | FC Dallas | 1.3 | 0–1 | 0.9 | NYCFC | 13,656 | Toyota Stadium | Victor Rivas | Match Report | |
| Wed | 2022-07-13 | 20:00 | Inter Miami | 0.8 | 1–2 | 1.4 | Philadelphia | 10,027 | DRV PNK Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-07-13 | 20:00 | D.C. United | 3.0 | 2–2 | 0.3 | Crew | 10,128 | Audi Field | Rosendo Mendoza | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-16 | 19:30 | CF Montréal | 2.2 | 1–0 | 0.3 | Toronto FC | 19,619 | Stade Saputo | Ted Unkel | Match Report | |
| Sat | 2022-07-16 | 19:30 | Philadelphia | 1.4 | 2–1 | 1.3 | NE Revolution | 18,257 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sun | 2022-07-17 | 15:00 | Atlanta Utd | 2.2 | 1–1 | 0.2 | Orlando City | 42,526 | Mercedes-Benz Stadium | Victor Rivas | Match Report | |
| Sun | 2022-07-17 | 17:00 | NY Red Bulls | 0.9 | 0–1 | 1.4 | NYCFC | 25,219 | Red Bull Arena | Chris Penso | Match Report | |
| Sat | 2022-07-16 | 19:00 | Rapids | 1.6 | 2–0 | 1.0 | LA Galaxy | 17,975 | Dick's Sporting Goods Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-07-16 | 19:00 | Fire | 1.0 | 1–0 | 0.9 | Seattle | 13,601 | Soldier Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-07-16 | 19:00 | Minnesota Utd | 1.9 | 2–0 | 0.3 | D.C. United | 19,718 | Allianz Field | Jair Marrufo | Match Report | |
| Sun | 2022-07-17 | 19:30 | Crew | 2.2 | 2–0 | 1.0 | FC Cincinnati | 20,741 | Lower.com Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-07-16 | 20:00 | FC Dallas | 2.1 | 1–1 | 0.7 | Austin | 16,833 | Toyota Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-07-16 | 20:30 | Inter Miami | 1.4 | 3–2 | 0.5 | Charlotte | 12,274 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Sun | 2022-07-17 | 18:30 | SJ Earthquakes | 2.2 | 1–2 | 1.3 | Dynamo FC | 13,445 | PayPal Park | Tim Ford | Match Report | |
| Sun | 2022-07-17 | 19:30 | Nashville | 2.0 | 1–2 | 1.6 | LAFC | 30,109 | Geodis Park | Drew Fischer | Match Report | |
| Sun | 2022-07-17 | 19:30 | RSL | 2.0 | 3–0 | 0.3 | Sporting KC | 20,132 | Rio Tinto Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-07-17 | 19:30 | Portland Timbers | 2.3 | 1–1 | 1.7 | Vancouver W'caps | 24,337 | Providence Park | Ramy Touchan | Match Report | |
| Sat | 2022-07-23 | 19:00 | NYCFC | 1.8 | 2–0 | 0.7 | Inter Miami | 23,277 | Yankee Stadium | Allen Chapman | Match Report | |
| Sat | 2022-07-23 | 19:30 | Crew | 1.0 | 0–0 | 0.2 | NE Revolution | 20,383 | Lower.com Field | Silviu Petrescu | Match Report | |
| Sat | 2022-07-23 | 19:30 | Orlando City | 0.7 | 0–1 | 0.8 | Philadelphia | 16,031 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-07-23 | 19:30 | Toronto FC | 1.2 | 4–0 | 0.7 | Charlotte | 29,067 | BMO Field | Filip Dujic | Match Report | |
| Sat | 2022-07-23 | 19:30 | FC Cincinnati | 1.4 | 1–1 | 1.6 | Nashville | 23,420 | TQL Stadium | Chris Penso | Match Report | |
| Sat | 2022-07-23 | 19:00 | Vancouver W'caps | 1.3 | 1–3 | 1.1 | Fire | 14,984 | BC Place Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-07-23 | 19:00 | Seattle | 2.8 | 2–1 | 1.3 | Rapids | 32,476 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2022-07-23 | 19:30 | Portland Timbers | 1.7 | 2–1 | 1.3 | SJ Earthquakes | 23,795 | Providence Park | Jon Freemon | Match Report | |
| Sat | 2022-07-23 | 19:30 | Sporting KC | 0.5 | 0–2 | 1.0 | LAFC | 20,142 | Children's Mercy Park | Lukasz Szpala | Match Report | |
| Sat | 2022-07-23 | 19:30 | Dynamo FC | 1.5 | 1–2 | 1.3 | Minnesota Utd | 15,223 | PNC Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-07-23 | 20:00 | D.C. United | 1.5 | 1–2 | 1.5 | CF Montréal | 15,734 | Audi Field | Rubiel Vazquez | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-23 | 20:00 | RSL | 2.1 | 0–1 | 0.7 | FC Dallas | 20,437 | Rio Tinto Stadium | Matt Conger | Match Report | |
| Sun | 2022-07-24 | 18:30 | LA Galaxy | 1.9 | 2–0 | 1.2 | Atlanta Utd | 24,122 | Dignity Health Sports Park | Marcos de Oliveira | Match Report | |
| Sun | 2022-07-24 | 19:00 | Austin | 1.6 | 3–4 | 0.9 | NY Red Bulls | 20,738 | Q2 Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-07-30 | 14:00 | Minnesota Utd | 2.3 | 4–4 | 1.3 | Portland Timbers | 19,792 | Allianz Field | Victor Rivas | Match Report | |
| Sat | 2022-07-30 | 16:00 | Fire | 1.0 | 0–0 | 1.3 | Atlanta Utd | 23,951 | Soldier Field | Tim Ford | Match Report | |
| Sat | 2022-07-30 | 19:30 | Philadelphia | 2.6 | 6–0 | 0.6 | Dynamo FC | 19,089 | Subaru Park | Kevin Stott | Match Report | |
| Sat | 2022-07-30 | 19:30 | CF Montréal | 0.8 | 0–0 | 0.1 | NYCFC | 19,619 | Stade Saputo | Ramy Touchan | Match Report | |
| Fri | 2022-07-29 | 20:00 | LAFC | 1.6 | 2–1 | 0.9 | Seattle | 22,111 | Banc of California Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-07-31 | 17:00 | D.C. United | 1.0 | 2–1 | 1.6 | Orlando City | 15,805 | Audi Field | Armando Villarreal | Match Report | |
| Sat | 2022-07-30 | 19:00 | SJ Earthquakes | 1.5 | 2–2 | 1.6 | RSL | 12,411 | PayPal Park | Nima Saghafi | Match Report | |
| Sat | 2022-07-30 | 19:00 | Nashville | 1.8 | 1–1 | 1.3 | Vancouver W'caps | 26,578 | Geodis Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-07-30 | 19:30 | Sporting KC | 1.5 | 0–2 | 0.8 | Austin | 17,287 | Children's Mercy Park | Fotis Bazakos | Match Report | |
| Sat | 2022-07-30 | 20:00 | Inter Miami | 2.5 | 4–4 | 2.6 | FC Cincinnati | DRV PNK Stadium | Tori Penso | Match Report | ||
| Sat | 2022-07-30 | 20:00 | FC Dallas | 1.1 | 1–0 | 1.4 | LA Galaxy | 19,096 | Toyota Stadium | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-07-30 | 20:00 | NE Revolution | 0.6 | 0–0 | 1.7 | Toronto FC | 29,097 | Gillette Stadium | Ismir Pekmic | Match Report | |
| Tue | 2022-08-02 | 19:30 | NY Red Bulls | 2.4 | 4–5 | 1.5 | Rapids | 13,812 | Red Bull Arena | Drew Fischer | Match Report | |
| Wed | 2022-08-03 | 19:00 | Charlotte | 2.2 | 3–0 | 0.5 | D.C. United | 31,520 | Bank of America Stadium | Guido Gonzalez Jr. | Match Report | |
| Tue | 2022-08-02 | 19:00 | Seattle | 1.3 | 1–0 | 0.5 | FC Dallas | 32,207 | Lumen Field | Allen Chapman | Match Report | |
| Wed | 2022-08-03 | 19:30 | Crew | 1.3 | 1–2 | 1.2 | CF Montréal | 19,010 | Lower.com Field | Lukasz Szpala | Match Report | |
| Wed | 2022-08-03 | 19:30 | SJ Earthquakes | 1.3 | 0–1 | 1.4 | Inter Miami | 11,806 | PayPal Park | Mark Allatin | Match Report | |
| Wed | 2022-08-03 | 19:30 | Portland Timbers | 1.5 | 1–1 | 1.3 | Nashville | 23,101 | Providence Park | Silviu Petrescu | Match Report | |
| Sat | 2022-08-06 | 15:00 | Atlanta Utd | 1.0 | 2–1 | 1.2 | Seattle | 68,586 | Mercedes-Benz Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-08-06 | 19:00 | Charlotte | 1.3 | 2–3 | 2.2 | Fire | 32,538 | Bank of America Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-06 | 19:30 | Crew | 0.6 | 3–2 | 1.5 | NYCFC | 18,609 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-08-06 | 19:30 | CF Montréal | 1.7 | 2–2 | 0.6 | Inter Miami | 18,007 | Stade Saputo | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-06 | 19:30 | D.C. United | 0.3 | 0–0 | 0.7 | NY Red Bulls | 16,258 | Audi Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-08-06 | 19:30 | FC Cincinnati | 1.7 | 3–1 | 1.3 | Philadelphia | 23,443 | TQL Stadium | Drew Fischer | Match Report | |
| Fri | 2022-08-05 | 19:30 | Vancouver W'caps | 1.0 | 2–1 | 0.9 | Dynamo FC | 14,668 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-08-06 | 19:30 | Orlando City | 1.2 | 0–3 | 1.0 | NE Revolution | Exploria Stadium | Ramy Touchan | Match Report | ||
| Sat | 2022-08-06 | 19:00 | Rapids | 3.2 | 4–3 | 1.4 | Minnesota Utd | 14,738 | Dick's Sporting Goods Park | Ismir Pekmic | Match Report | |
| Sat | 2022-08-06 | 19:00 | Nashville | 2.4 | 3–4 | 1.8 | Toronto FC | 26,326 | Geodis Park | Allen Chapman | Match Report | |
| Sat | 2022-08-06 | 19:30 | Portland Timbers | 1.2 | 1–1 | 0.8 | FC Dallas | 24,114 | Providence Park | Ted Unkel | Match Report | |
| Sat | 2022-08-06 | 19:30 | Sporting KC | 3.3 | 4–2 | 1.5 | LA Galaxy | 18,101 | Children's Mercy Park | Michael Radchuk | Match Report | |
| Sat | 2022-08-06 | 20:00 | RSL | 0.7 | 1–4 | 1.4 | LAFC | 21,810 | Rio Tinto Stadium | Victor Rivas | Match Report | |
| Sat | 2022-08-06 | 20:00 | Austin | 2.6 | 3–3 | 0.8 | SJ Earthquakes | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-08-13 | 18:00 | NY Red Bulls | 0.5 | 0–1 | 0.2 | Orlando City | 18,218 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| Sat | 2022-08-13 | 19:30 | FC Cincinnati | 1.4 | 2–2 | 1.3 | Atlanta Utd | 25,037 | TQL Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-08-13 | 19:30 | NE Revolution | 2.4 | 1–0 | 0.7 | D.C. United | 24,240 | Gillette Stadium | Malik Badawi | Match Report | |
| Sat | 2022-08-13 | 19:30 | Philadelphia | 2.6 | 4–1 | 1.3 | Fire | 18,682 | Subaru Park | Ismail Elfath | Match Report | |
| Sat | 2022-08-13 | 19:30 | Toronto FC | 2.5 | 3–1 | 0.5 | Portland Timbers | 28,598 | BMO Field | Nima Saghafi | Match Report | |
| Sat | 2022-08-13 | 19:00 | Rapids | 1.2 | 1–1 | 1.3 | Crew | 13,254 | Dick's Sporting Goods Park | Jon Freemon | Match Report | |
| Sat | 2022-08-13 | 19:00 | LA Galaxy | 2.9 | 5–2 | 1.0 | Vancouver W'caps | 21,465 | Dignity Health Sports Park | Silviu Petrescu | Match Report | |
| Sat | 2022-08-13 | 19:30 | LAFC | 2.6 | 5–0 | 0.2 | Charlotte | 22,140 | Banc of California Stadium | Chris Penso | Match Report | |
| Sat | 2022-08-13 | 20:00 | Inter Miami | 1.9 | 3–2 | 2.2 | NYCFC | 11,419 | DRV PNK Stadium | Drew Fischer | Match Report | |
| Sat | 2022-08-13 | 20:00 | Dynamo FC | 0.7 | 2–3 | 2.1 | CF Montréal | 21,284 | PNC Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-08-13 | 20:00 | FC Dallas | 1.6 | 4–1 | 0.6 | SJ Earthquakes | 15,106 | Toyota Stadium | Victor Rivas | Match Report | |
| Sat | 2022-08-13 | 20:00 | Austin | 1.3 | 4–3 | 2.6 | Sporting KC | 20,738 | Q2 Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-08-14 | 19:00 | Seattle | 1.9 | 1–2 | 1.2 | RSL | 33,093 | Lumen Field | Tim Ford | Match Report | |
| Sun | 2022-08-14 | 20:00 | Nashville | 1.5 | 1–2 | 1.0 | Minnesota Utd | 25,240 | Geodis Park | Alex Chilowicz | Match Report | |
| Wed | 2022-08-17 | 19:30 | Toronto FC | 1.7 | 2–2 | 1.1 | NE Revolution | 28,464 | BMO Field | Fotis Bazakos | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Tue | 2022-08-16 | 19:30 | LAFC | 2.0 | 1–0 | 0.6 | D.C. United | 22,063 | Banc of California Stadium | Ramy Touchan | Match Report | |
| Wed | 2022-08-17 | 19:30 | Atlanta Utd | 0.9 | 1–2 | 0.9 | NY Red Bulls | 42,555 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Wed | 2022-08-17 | 19:00 | Vancouver W'caps | 1.0 | 2–1 | 2.4 | Rapids | 14,682 | BC Place Stadium | Filip Dujic | Match Report | |
| Wed | 2022-08-17 | 20:00 | NYCFC | 1.2 | 1–3 | 1.7 | Charlotte | 8,531 | Red Bull Arena | Jon Freemon | Match Report | |
| Wed | 2022-08-17 | 20:00 | FC Dallas | 0.9 | 1–0 | 0.5 | Philadelphia | 12,479 | Toyota Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-20 | 18:00 | NY Red Bulls | 1.6 | 1–1 | 0.4 | FC Cincinnati | 16,525 | Red Bull Arena | Ismail Elfath | Match Report | |
| Fri | 2022-08-19 | 19:00 | LA Galaxy | 1.5 | 3–3 | 2.5 | Seattle | 23,278 | Dignity Health Sports Park | Victor Rivas | Match Report | |
| Sat | 2022-08-20 | 19:30 | CF Montréal | 3.1 | 4–0 | 1.0 | NE Revolution | 19,619 | Stade Saputo | Chris Penso | Match Report | |
| Sat | 2022-08-20 | 19:30 | D.C. United | 1.5 | 0–6 | 3.6 | Philadelphia | 17,941 | Audi Field | Ted Unkel | Match Report | |
| Sun | 2022-08-21 | 17:00 | Fire | 1.7 | 0–2 | 1.0 | NYCFC | 11,720 | Soldier Field | Rosendo Mendoza | Match Report | |
| Sun | 2022-08-21 | 17:30 | Crew | 0.7 | 2–2 | 2.0 | Atlanta Utd | 17,461 | Lower.com Field | Joe Dickerson | Match Report | |
| Sun | 2022-08-21 | 18:30 | Sporting KC | 1.3 | 4–1 | 1.3 | Portland Timbers | 17,348 | Children's Mercy Park | Armando Villarreal | Match Report | |
| Sat | 2022-08-20 | 19:00 | Minnesota Utd | 2.1 | 2–1 | 1.4 | Austin | 19,829 | Allianz Field | Allen Chapman | Match Report | |
| Sun | 2022-08-21 | 19:00 | Charlotte | 0.7 | 1–2 | 1.4 | Orlando City | 30,855 | Bank of America Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-08-20 | 19:00 | Rapids | 0.7 | 1–1 | 0.4 | Dynamo FC | 15,380 | Dick's Sporting Goods Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-08-20 | 19:00 | SJ Earthquakes | 0.9 | 2–1 | 1.3 | LAFC | 18,000 | PayPal Park | Michael Radchuk | Match Report | |
| Sat | 2022-08-20 | 20:00 | RSL | 1.0 | 1–1 | 0.7 | Vancouver W'caps | 20,567 | Rio Tinto Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-08-20 | 20:00 | Inter Miami | 0.8 | 2–1 | 0.8 | Toronto FC | 14,388 | DRV PNK Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-08-21 | 19:30 | Nashville | 1.8 | 4–0 | 0.2 | FC Dallas | 25,571 | Geodis Park | Kevin Stott | Match Report | |
| Sat | 2022-08-27 | 14:30 | Minnesota Utd | 0.9 | 2–1 | 0.7 | Dynamo FC | 19,624 | Allianz Field | Rosendo Mendoza | Match Report | |
| Fri | 2022-08-26 | 19:00 | Austin | 0.6 | 4–1 | 1.5 | LAFC | 20,738 | Q2 Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-08-27 | 19:00 | Charlotte | 1.1 | 0–2 | 0.7 | Toronto FC | 32,495 | Bank of America Stadium | Tim Ford | Match Report | |
| Sat | 2022-08-27 | 19:00 | NY Red Bulls | 1.2 | 3–1 | 1.9 | Inter Miami | 21,374 | Red Bull Arena | Fotis Bazakos | Match Report | |
| Fri | 2022-08-26 | 19:00 | Portland Timbers | 2.6 | 2–1 | 0.7 | Seattle | 25,218 | Providence Park | Ismail Elfath | Match Report | |
| Sat | 2022-08-27 | 19:30 | FC Cincinnati | 1.4 | 2–2 | 0.4 | Crew | 25,037 | TQL Stadium | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-27 | 19:30 | Philadelphia | 5.7 | 6–0 | 0.8 | Rapids | 18,005 | Subaru Park | Allen Chapman | Match Report | |
| Sun | 2022-08-28 | 16:00 | Atlanta Utd | 2.1 | 3–2 | 1.1 | D.C. United | 42,561 | Mercedes-Benz Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-27 | 19:00 | Fire | 0.9 | 0–2 | 1.1 | CF Montréal | 13,907 | Soldier Field | Michael Radchuk | Match Report | |
| Sat | 2022-08-27 | 19:00 | Vancouver W'caps | 0.5 | 0–3 | 1.5 | Nashville | 16,351 | BC Place Stadium | Jon Freemon | Match Report | |
| Sun | 2022-08-28 | 19:30 | Orlando City | 1.2 | 2–1 | 0.5 | NYCFC | Exploria Stadium | Chris Penso | Match Report | ||
| Sat | 2022-08-27 | 19:30 | Sporting KC | 1.5 | 1–0 | 1.0 | SJ Earthquakes | 18,241 | Children's Mercy Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-08-27 | 20:00 | FC Dallas | 0.8 | 1–1 | 1.3 | RSL | 15,573 | Toyota Stadium | Ramy Touchan | Match Report | |
| Sun | 2022-08-28 | 20:00 | NE Revolution | 1.9 | 1–2 | 0.9 | LA Galaxy | 21,517 | Gillette Stadium | Lukasz Szpala | Match Report | |
| Wed | 2022-08-31 | 19:00 | Philadelphia | 2.9 | 4–1 | 1.5 | Atlanta Utd | 18,214 | Subaru Park | Lukasz Szpala | Match Report | |
| Wed | 2022-08-31 | 19:30 | CF Montréal | 0.9 | 0–1 | 0.7 | NY Red Bulls | 15,075 | Stade Saputo | Victor Rivas | Match Report | |
| Wed | 2022-08-31 | 19:30 | Crew | 0.8 | 1–0 | 0.3 | Inter Miami | 18,034 | Lower.com Field | Armando Villarreal | Match Report | |
| Wed | 2022-08-31 | 19:30 | Toronto FC | 1.9 | 2–2 | 0.5 | LA Galaxy | 29,130 | BMO Field | Ted Unkel | Match Report | |
| Wed | 2022-08-31 | 19:30 | NE Revolution | 1.3 | 0–0 | 1.5 | Fire | 13,325 | Gillette Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-08-31 | 19:30 | Nashville | 2.7 | 4–1 | 0.8 | Rapids | 24,127 | Geodis Park | Mark Allatin | Match Report | |
| Wed | 2022-08-31 | 19:30 | Dynamo FC | 1.4 | 2–1 | 2.7 | LAFC | 21,284 | PNC Stadium | Matt Conger | Match Report | |
| Wed | 2022-08-31 | 19:30 | RSL | 1.7 | 3–0 | 0.3 | Minnesota Utd | 20,358 | Rio Tinto Stadium | Drew Fischer | Match Report | |
| Wed | 2022-08-31 | 20:00 | NYCFC | 0.4 | 1–2 | 1.2 | D.C. United | 8,113 | Yankee Stadium | Ismir Pekmic | Match Report | |
| Wed | 2022-08-31 | 20:00 | Austin | 2.2 | 1–2 | 2.0 | Portland Timbers | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Wed | 2022-08-31 | 22:00 | Orlando City | 3.4 | 3–2 | 0.5 | Seattle | 14,483 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-09-03 | 14:30 | Minnesota Utd | 1.2 | 0–3 | 0.9 | FC Dallas | 19,761 | Allianz Field | Ismail Elfath | Match Report | |
| Sat | 2022-09-03 | 17:30 | Crew | 1.1 | 0–0 | 0.2 | Fire | 18,189 | Lower.com Field | Ismir Pekmic | Match Report | |
| Sat | 2022-09-03 | 19:00 | NY Red Bulls | 1.2 | 0–2 | 0.8 | Philadelphia | 16,247 | Red Bull Arena | Tim Ford | Match Report | |
| Sat | 2022-09-03 | 19:30 | FC Cincinnati | 1.1 | 2–0 | 0.9 | Charlotte | 21,165 | TQL Stadium | Michael Radchuk | Match Report | |
| Sun | 2022-09-04 | 14:30 | Portland Timbers | 2.6 | 2–1 | 1.2 | Atlanta Utd | 24,438 | Providence Park | Jon Freemon | Match Report | |
| Sat | 2022-09-03 | 19:30 | Nashville | 1.8 | 3–0 | 0.9 | Austin | 25,293 | Geodis Park | Nima Saghafi | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-09-04 | 19:30 | Toronto FC | 1.7 | 3–4 | 2.1 | CF Montréal | 28,793 | BMO Field | Allen Chapman | Match Report | |
| Sun | 2022-09-04 | 19:30 | D.C. United | 1.7 | 0–0 | 1.0 | Rapids | 16,502 | Audi Field | Tori Penso | Match Report | |
| Sun | 2022-09-04 | 17:00 | LA Galaxy | 2.5 | 2–2 | 1.5 | Sporting KC | 20,104 | Dignity Health Sports Park | Ramy Touchan | Match Report | |
| Sun | 2022-09-04 | 18:00 | Seattle | 2.3 | 2–1 | 0.4 | Dynamo FC | 33,621 | Lumen Field | Silviu Petrescu | Match Report | |
| Sun | 2022-09-04 | 18:30 | SJ Earthquakes | 0.7 | 2–0 | 1.4 | Vancouver W'caps | 13,211 | PayPal Park | Rosendo Mendoza | Match Report | |
| Sun | 2022-09-04 | 19:30 | LAFC | 3.1 | 2–0 | 0.3 | RSL | 22,199 | Banc of California Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-09-04 | 20:00 | NE Revolution | 0.4 | 3–0 | 2.1 | NYCFC | 17,793 | Gillette Stadium | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-09-07 | 20:00 | NYCFC | 1.5 | 1–1 | 0.2 | FC Cincinnati | 14,248 | Citi Field | Ted Unkel | Match Report | |
| Fri | 2022-09-09 | 19:30 | CF Montréal | 2.3 | 2–2 | 0.7 | Crew | 19,619 | Stade Saputo | Lukasz Szpala | Match Report | |
| Sat | 2022-09-10 | 13:00 | Charlotte | 0.7 | 1–0 | 0.8 | NYCFC | 30,159 | Bank of America Stadium | Victor Rivas | Match Report | |
| Sat | 2022-09-10 | 14:30 | Nashville | 1.4 | 1–1 | 2.6 | LA Galaxy | 28,753 | Geodis Park | Chris Penso | Match Report | |
| Sat | 2022-09-10 | 18:00 | NY Red Bulls | 1.6 | 2–1 | 0.5 | NE Revolution | 16,301 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Sat | 2022-09-10 | 19:30 | Philadelphia | 2.8 | 5–1 | 0.4 | Orlando City | 19,079 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2022-09-10 | 19:30 | Atlanta Utd | 4.1 | 4–2 | 2.4 | Toronto FC | 42,670 | Mercedes-Benz Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-09-10 | 19:30 | FC Cincinnati | 3.8 | 6–0 | 0.9 | SJ Earthquakes | 22,557 | TQL Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-09-10 | 17:00 | Seattle | 1.1 | 3–0 | 1.1 | Austin | 34,721 | Lumen Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-09-10 | 19:00 | Fire | 1.7 | 3–1 | 1.1 | Inter Miami | 15,104 | SeatGeek Stadium | Matt Conger | Match Report | |
| Sat | 2022-09-10 | 19:00 | Portland Timbers | 1.1 | 1–0 | 2.4 | Minnesota Utd | 25,019 | Providence Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-09-10 | 19:30 | RSL | 0.5 | 0–0 | 0.6 | D.C. United | 20,487 | Rio Tinto Stadium | Kevin Broadley | Match Report | |
| Sat | 2022-09-10 | 19:30 | Rapids | 2.2 | 3–1 | 0.9 | Vancouver W'caps | 14,036 | Dick's Sporting Goods Park | Kevin Stott | Match Report | |
| Sat | 2022-09-10 | 19:30 | Dynamo FC | 1.3 | 0–0 | 1.3 | Sporting KC | 15,169 | PNC Stadium | Tori Penso | Match Report | |
| Sat | 2022-09-10 | 19:30 | FC Dallas | 0.9 | 2–1 | 1.1 | LAFC | 19,096 | Toyota Stadium | Jon Freemon | Match Report | |
| Tue | 2022-09-13 | 19:30 | CF Montréal | 0.9 | 3–2 | 1.7 | Fire | 11,535 | Stade Saputo | Ted Unkel | Match Report | |
| Wed | 2022-09-14 | 18:00 | Orlando City | 1.3 | 0–1 | 2.0 | Atlanta Utd | 15,340 | Exploria Stadium | Rubiel Vazquez | Match Report | |
| Tue | 2022-09-13 | 19:00 | Minnesota Utd | 1.6 | 1–1 | 1.1 | LAFC | 19,861 | Allianz Field | Tim Ford | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Tue | 2022-09-13 | 19:30 | Dynamo FC | 4.4 | 3–1 | 2.1 | NE Revolution | 10,305 | PNC Stadium | Ismail Elfath | Match Report | |
| Tue | 2022-09-13 | 19:30 | Sporting KC | 1.9 | 3–0 | 0.4 | D.C. United | 15,106 | Children's Mercy Park | Rosendo Mendoza | Match Report | |
| Tue | 2022-09-13 | 20:00 | Inter Miami | 0.9 | 2–1 | 1.0 | Crew | 9,778 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Wed | 2022-09-14 | 19:00 | Vancouver W'caps | 1.6 | 3–0 | 0.7 | LA Galaxy | 16,681 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Wed | 2022-09-14 | 20:00 | Rapids | 0.7 | 2–1 | 1.2 | SJ Earthquakes | 11,938 | Dick's Sporting Goods Park | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-09-14 | 20:15 | Austin | 1.9 | 3–0 | 1.2 | RSL | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-09-17 | 13:00 | NYCFC | 1.0 | 2–0 | 0.7 | NY Red Bulls | 30,151 | Yankee Stadium | Allen Chapman | Match Report | |
| Sat | 2022-09-17 | 15:30 | Atlanta Utd | 1.3 | 0–0 | 0.2 | Philadelphia | 42,521 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-09-17 | 19:30 | Orlando City | 1.0 | 4–0 | 0.7 | Toronto FC | 17,189 | Exploria Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-09-17 | 19:30 | NE Revolution | 0.8 | 0–1 | 1.3 | CF Montréal | 35,455 | Gillette Stadium | Rosendo Mendoza | Match Report | |
| Sun | 2022-09-18 | 13:00 | Crew | 1.1 | 1–1 | 0.8 | Portland Timbers | 20,421 | Lower.com Field | Victor Rivas | Match Report | |
| Sun | 2022-09-18 | 17:00 | D.C. United | 0.8 | 2–3 | 1.2 | Inter Miami | 14,284 | Audi Field | Ismail Elfath | Match Report | |
| Sat | 2022-09-17 | 19:00 | Vancouver W'caps | 1.2 | 2–1 | 0.6 | Seattle | 19,722 | BC Place Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-09-17 | 19:00 | Fire | 1.6 | 2–3 | 2.1 | Charlotte | 21,450 | Soldier Field | Tori Penso | Match Report | |
| Sat | 2022-09-17 | 19:30 | Sporting KC | 1.6 | 4–1 | 0.4 | Minnesota Utd | 19,680 | Children's Mercy Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-09-17 | 19:30 | RSL | 1.6 | 1–2 | 0.6 | FC Cincinnati | 20,222 | Rio Tinto Stadium | Chris Penso | Match Report | |
| Sat | 2022-09-17 | 19:30 | SJ Earthquakes | 1.8 | 1–1 | 1.1 | FC Dallas | 12,355 | PayPal Park | Drew Fischer | Match Report | |
| Sat | 2022-09-17 | 19:30 | LA Galaxy | 1.9 | 4–1 | 1.1 | Rapids | 20,325 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sat | 2022-09-17 | 20:00 | Austin | 0.8 | 1–1 | 1.4 | Nashville | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-09-18 | 19:30 | LAFC | 3.0 | 3–1 | 0.9 | Dynamo FC | 22,131 | Banc of California Stadium | Kevin Stott | Match Report | |
| Sat | 2022-09-24 | 19:00 | SJ Earthquakes | 1.8 | 2–3 | 1.5 | LA Galaxy | 44,200 | Stanford Stadium | Alex Chilowicz | Match Report | |
| Tue | 2022-09-27 | 19:00 | Seattle | 0.4 | 1–1 | 2.0 | FC Cincinnati | 31,291 | Lumen Field | Rubiel Vazquez | Match Report | |
| Fri | 2022-09-30 | 19:30 | Toronto FC | 0.9 | 0–1 | 1.1 | Inter Miami | 27,703 | BMO Field | Silviu Petrescu | Match Report | |
| Sat | 2022-10-01 | 13:30 | NE Revolution | 2.4 | 2–1 | 1.3 | Atlanta Utd | 33,421 | Gillette Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-10-01 | 15:30 | Rapids | 0.6 | 1–0 | 0.8 | FC Dallas | 17,193 | Dick's Sporting Goods Park | Chris Penso | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-10-01 | 17:30 | Charlotte | 2.9 | 4–0 | 0.8 | Philadelphia | 43,860 | Bank of America Stadium | Jon Freemon | Match Report | |
| Sat | 2022-10-01 | 19:30 | Crew | 1.1 | 2–1 | 0.5 | NY Red Bulls | 20,757 | Lower.com Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-10-01 | 19:30 | FC Cincinnati | 2.5 | 2–3 | 1.6 | Fire | 25,316 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-10-01 | 19:30 | CF Montréal | 2.0 | 1–0 | 0.6 | D.C. United | 19,619 | Stade Saputo | Ramy Touchan | Match Report | |
| Sun | 2022-10-02 | 12:00 | Portland Timbers | 1.2 | 1–2 | 1.0 | LAFC | 25,218 | Providence Park | Ismail Elfath | Match Report | |
| Sun | 2022-10-02 | 13:00 | NYCFC | 1.9 | 2–1 | 1.0 | Orlando City | 13,169 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sun | 2022-10-02 | 16:00 | Sporting KC | 1.7 | 1–0 | 1.1 | Seattle | 19,439 | Children's Mercy Park | Ted Unkel | Match Report | |
| Sat | 2022-10-01 | 19:00 | Vancouver W'caps | 1.5 | 2–0 | 1.4 | Austin | 19,292 | BC Place Stadium | Tim Ford | Match Report | |
| Sat | 2022-10-01 | 19:00 | SJ Earthquakes | 1.6 | 2–0 | 1.2 | Minnesota Utd | 15,709 | PayPal Park | Nima Saghafi | Match Report | |
| Sat | 2022-10-01 | 19:30 | LA Galaxy | 2.4 | 1–1 | 1.6 | RSL | 26,674 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Sun | 2022-10-02 | 19:30 | Nashville | 1.3 | 1–2 | 1.9 | Dynamo FC | 28,720 | Geodis Park | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-10-05 | 19:00 | Charlotte | 2.4 | 2–2 | 1.2 | Crew | 34,122 | Bank of America Stadium | Matt Conger | Match Report | |
| Wed | 2022-10-05 | 20:00 | Inter Miami | 2.0 | 4–1 | 0.8 | Orlando City | 15,228 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sun | 2022-10-09 | 13:30 | Fire | 2.1 | 1–1 | 1.5 | NE Revolution | 14,357 | SeatGeek Stadium | Michael Radchuk | Match Report | |
| Sun | 2022-10-09 | 14:00 | LAFC | 4.5 | 0–1 | 1.2 | Nashville | 22,205 | Banc of California Stadium | Ted Unkel | Match Report | |
| Sun | 2022-10-09 | 14:00 | Seattle | 1.3 | 2–2 | 1.5 | SJ Earthquakes | 33,910 | Lumen Field | Marcos de Oliveira | Match Report | |
| Sun | 2022-10-09 | 14:30 | Philadelphia | 2.0 | 4–0 | 0.4 | Toronto FC | 19,228 | Subaru Park | Lukasz Szpala | Match Report | |
| Sun | 2022-10-09 | 14:30 | Inter Miami | 0.8 | 1–3 | 2.4 | CF Montréal | 15,635 | DRV PNK Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-10-09 | 14:30 | Atlanta Utd | 1.5 | 1–2 | 1.4 | NYCFC | 43,312 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sun | 2022-10-09 | 14:30 | NY Red Bulls | 0.9 | 2–0 | 1.0 | Charlotte | 23,672 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| Sun | 2022-10-09 | 14:30 | D.C. United | 0.4 | 2–5 | 2.1 | FC Cincinnati | 19,325 | Audi Field | Tim Ford | Match Report | |
| Sun | 2022-10-09 | 14:30 | Orlando City | 1.1 | 2–1 | 0.9 | Crew | 21,693 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sun | 2022-10-09 | 15:00 | RSL | 1.7 | 3–1 | 0.8 | Portland Timbers | 21,333 | Rio Tinto Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-10-09 | 16:00 | FC Dallas | 1.3 | 2–1 | 0.9 | Sporting KC | 19,096 | Toyota Stadium | Victor Rivas | Match Report | |
| Sun | 2022-10-09 | 16:00 | Dynamo FC | 0.6 | 1–3 | 2.3 | LA Galaxy | 21,284 | PNC Stadium | Drew Fischer | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-10-09 | 16:00 | Austin | 1.6 | 1–1 | 1.2 | Rapids | 20,738 | Q2 Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-10-09 | 16:00 | Minnesota Utd | 0.9 | 2–0 | 0.6 | Vancouver W'caps | 19,941 | Allianz Field | Allen Chapman | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First Round | Sat | 2022-10-15 | 12:00 | NY Red Bulls | 1.1 | 1–2 | 2.1 | FC Cincinnati | 17,113 | Red Bull Arena | Alex Chilowicz | Match Report | |
| First Round | Sat | 2022-10-15 | 12:00 | LA Galaxy | 1.2 | 1–0 | 0.8 | Nashville | 22,280 | Dignity Health Sports Park | Armando Villarreal | Match Report | |
| First Round | Sun | 2022-10-16 | 14:00 | Austin | 4.2 | (3) 2–2 (1) | 1.5 | RSL | 20,738 | Q2 Stadium | Victor Rivas | Match Report | Austin won on penalty kicks following extra time |
| First Round | Mon | 2022-10-17 | 19:00 | NYCFC | 2.9 | 3–0 | 0.6 | Inter Miami | 18,066 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| First Round | Sun | 2022-10-16 | 20:00 | CF Montréal | 1.6 | 2–0 | 0.7 | Orlando City | 19,619 | Stade Saputo | Ismail Elfath | Match Report | |
| First Round | Mon | 2022-10-17 | 20:30 | FC Dallas | 1.5 | (5) 1–1 (4) | 0.4 | Minnesota Utd | 19,096 | Toyota Stadium | Ted Unkel | Match Report | FC Dallas won on penalty kicks following extra time |
| Conference Semifinals | Thu | 2022-10-20 | 19:00 | LAFC | 2.5 | 3–2 | 0.4 | LA Galaxy | 22,305 | Banc of California Stadium | Allen Chapman | Match Report | |
| Conference Semifinals | Thu | 2022-10-20 | 20:00 | Philadelphia | 1.8 | 1–0 | 0.8 | FC Cincinnati | 19,289 | Subaru Park | Tim Ford | Match Report | |
| Conference Semifinals | Sun | 2022-10-23 | 13:00 | CF Montréal | 2.6 | 1–3 | 1.8 | NYCFC | 19,619 | Stade Saputo | Drew Fischer | Match Report | |
| Conference Semifinals | Sun | 2022-10-23 | 19:00 | Austin | 1.4 | 2–1 | 0.6 | FC Dallas | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Conference Finals | Sun | 2022-10-30 | 12:00 | LAFC | 2.1 | 3–0 | 0.3 | Austin | 22,175 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Conference Finals | Sun | 2022-10-30 | 20:00 | Philadelphia | 1.7 | 3–1 | 0.6 | NYCFC | 19,770 | Subaru Park | Allen Chapman | Match Report | |
| MLS Cup | Sat | 2022-11-05 | 13:00 | LAFC | 1.0 | (3) 3–3 (0) | 1.6 | Philadelphia | 22,384 | Banc of California Stadium | Ismail Elfath | Match Report | LAFC won on penalty kicks following extra time |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
FBref is the most complete sources for women's football data on the internet. This includes the entire history of the FIFA Women's World Cup as well as recent domestic league seasons from nine countries, including advanced stats like xG for most of those nine.
In collaboration with Opta, we are including advanced analytical data such as xG, xA, progressive passing, duels and more for over twenty competitions. For more information on the expected goals model and which competitions have advanced data, see our xG explainer.
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