Scores & Fixtures 2021 Major League Soccer
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2021-04-17 | 14:00 | CF Montréal | 1.3 | 4–2 | 2.0 | Toronto FC | DRV PNK Stadium | Ismail Elfath | Match Report | ||
| Sat | 2021-04-17 | 15:00 | LAFC | 3.2 | 2–0 | 0.8 | Austin | 4,900 | Banc of California Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-04-17 | 15:00 | Orlando City | 1.4 | 0–0 | 1.2 | Atlanta Utd | 11,503 | Exploria Stadium | Jair Marrufo | Match Report | |
| Fri | 2021-04-16 | 18:30 | Seattle | 3.2 | 4–0 | 1.3 | Minnesota Utd | 7,042 | Lumen Field | Joe Dickerson | Match Report | |
| Fri | 2021-04-16 | 19:00 | Dynamo FC | 1.7 | 2–1 | 1.2 | SJ Earthquakes | BBVA Stadium | Armando Villarreal | Match Report | ||
| Sun | 2021-04-18 | 15:00 | Inter Miami | 2.9 | 2–3 | 1.7 | LA Galaxy | DRV PNK Stadium | Chris Penso | Match Report | ||
| Sun | 2021-04-18 | 17:30 | Crew | 1.1 | 0–0 | 1.3 | Philadelphia | 5,180 | MAPFRE Stadium | Ramy Touchan | Match Report | |
| Sat | 2021-04-17 | 19:00 | FC Dallas | 0.9 | 0–0 | 1.0 | Rapids | 8,621 | Toyota Stadium | Nima Saghafi | Match Report | |
| Sat | 2021-04-17 | 19:30 | Nashville | 3.7 | 2–2 | 2.1 | FC Cincinnati | Nissan Stadium | Rubiel Vazquez | Match Report | ||
| Sat | 2021-04-17 | 19:30 | Fire | 2.2 | 2–2 | 2.0 | NE Revolution | Soldier Field | Fotis Bazakos | Match Report | ||
| Sat | 2021-04-17 | 20:00 | NY Red Bulls | 0.9 | 1–2 | 2.0 | Sporting KC | Red Bull Arena | Robert Sibiga | Match Report | ||
| Sat | 2021-04-17 | 20:00 | D.C. United | 0.6 | 2–1 | 1.0 | NYCFC | 4,500 | Audi Field | Ted Unkel | Match Report | |
| Sun | 2021-04-18 | 20:00 | Vancouver W'caps | 0.5 | 1–0 | 1.2 | Portland Timbers | Rio Tinto Stadium | Allen Chapman | Match Report | ||
| Fri | 2021-04-23 | 18:30 | Sporting KC | 0.6 | 1–1 | 1.1 | Orlando City | Children's Mercy Park | Joe Dickerson | Match Report | ||
| Sat | 2021-04-24 | 12:30 | SJ Earthquakes | 3.3 | 3–1 | 1.5 | FC Dallas | Earthquakes Stadium | Tim Ford | Match Report | ||
| Sat | 2021-04-24 | 13:00 | NYCFC | 2.5 | 5–0 | 1.4 | FC Cincinnati | Yankee Stadium | Dave Gantar | Match Report | ||
| Sat | 2021-04-24 | 13:00 | Nashville | 2.7 | 2–2 | 0.8 | CF Montréal | Nissan Stadium | Fotis Bazakos | Match Report | ||
| Sat | 2021-04-24 | 15:00 | Toronto FC | 1.7 | 2–2 | 1.6 | Vancouver W'caps | Exploria Stadium | Jair Marrufo | Match Report | ||
| Sat | 2021-04-24 | 15:00 | LAFC | 0.6 | 1–1 | 0.8 | Seattle | Banc of California Stadium | Armando Villarreal | Match Report | ||
| Sun | 2021-04-25 | 14:30 | LA Galaxy | 2.0 | 3–2 | 1.2 | NY Red Bulls | Dignity Health Sports Park | Victor Rivas | Match Report | ||
| Sat | 2021-04-24 | 19:00 | Minnesota Utd | 1.7 | 1–2 | 1.4 | RSL | 4,100 | Allianz Field | Drew Fischer | Match Report | |
| Sat | 2021-04-24 | 19:00 | Rapids | 1.3 | 1–3 | 2.1 | Austin | Dick's Sporting Goods Park | Marcos de Oliveira | Match Report | ||
| Sat | 2021-04-24 | 19:30 | Portland Timbers | 2.6 | 2–1 | 1.2 | Dynamo FC | Providence Park | Ismail Elfath | Match Report | ||
| Sat | 2021-04-24 | 20:00 | NE Revolution | 0.2 | 1–0 | 0.3 | D.C. United | Gillette Stadium | Guido Gonzalez Jr. | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-04-24 | 20:00 | Atlanta Utd | 1.7 | 3–1 | 1.0 | Fire | 20,335 | Mercedes-Benz Stadium | Allen Chapman | Match Report | |
| Sat | 2021-04-24 | 20:00 | Philadelphia | 0.9 | 1–2 | 1.0 | Inter Miami | 5,000 | Subaru Park | Alex Chilowicz | Match Report | |
| Sat | 2021-05-01 | 12:00 | RSL | 1.2 | 3–1 | 0.3 | Sporting KC | Rio Tinto Stadium | Dave Gantar | Match Report | ||
| Sat | 2021-05-01 | 13:00 | NY Red Bulls | 1.6 | 2–0 | 0.3 | Fire | Red Bull Arena | Ted Unkel | Match Report | ||
| Sat | 2021-05-01 | 14:30 | Dynamo FC | 1.4 | 1–1 | 1.3 | LAFC | 7,850 | BBVA Stadium | Robert Sibiga | Match Report | |
| Sat | 2021-05-01 | 15:00 | CF Montréal | 1.6 | 0–0 | 0.2 | Crew | DRV PNK Stadium | Tim Ford | Match Report | ||
| Sat | 2021-05-01 | 19:00 | NE Revolution | 2.4 | 2–1 | 1.5 | Atlanta Utd | Gillette Stadium | Chris Penso | Match Report | ||
| Sat | 2021-05-01 | 19:30 | Philadelphia | 0.3 | 0–2 | 3.0 | NYCFC | Subaru Park | Ismail Elfath | Match Report | ||
| Sat | 2021-05-01 | 19:30 | Orlando City | 2.8 | 3–0 | 1.0 | FC Cincinnati | Exploria Stadium | Drew Fischer | Match Report | ||
| Sun | 2021-05-02 | 12:00 | Nashville | 0.9 | 0–0 | 0.4 | Inter Miami | 13,855 | Nissan Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-05-01 | 19:00 | Minnesota Utd | 0.9 | 0–1 | 1.8 | Austin | 4,100 | Allianz Field | Ramy Touchan | Match Report | |
| Sat | 2021-05-01 | 19:00 | FC Dallas | 1.8 | 4–1 | 0.8 | Portland Timbers | 8,621 | Toyota Stadium | Alan Kelly | Match Report | |
| Sat | 2021-05-01 | 20:00 | SJ Earthquakes | 2.0 | 4–1 | 2.0 | D.C. United | Earthquakes Stadium | Kevin Stott | Match Report | ||
| Sun | 2021-05-02 | 18:00 | Seattle | 2.1 | 3–0 | 0.9 | LA Galaxy | 7,148 | Lumen Field | Jair Marrufo | Match Report | |
| Sun | 2021-05-02 | 20:00 | Vancouver W'caps | 0.7 | 0–1 | 2.0 | Rapids | Rio Tinto Stadium | Baldomero Toledo | Match Report | ||
| Sat | 2021-05-08 | 12:00 | Fire | 1.0 | 0–2 | 1.4 | Philadelphia | 6,457 | Soldier Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-05-08 | 12:00 | Vancouver W'caps | 1.5 | 2–0 | 1.5 | CF Montréal | Rio Tinto Stadium | Rosendo Mendoza | Match Report | ||
| Sat | 2021-05-08 | 12:30 | Nashville | 1.4 | 2–0 | 0.9 | NE Revolution | 12,510 | Nissan Stadium | Victor Rivas | Match Report | |
| Sat | 2021-05-08 | 13:00 | NY Red Bulls | 1.7 | 2–0 | 0.4 | Toronto FC | Red Bull Arena | Guido Gonzalez Jr. | Match Report | ||
| Sat | 2021-05-08 | 13:30 | Crew | 0.4 | 3–1 | 1.0 | D.C. United | 5,180 | MAPFRE Stadium | Silviu Petrescu | Match Report | |
| Sat | 2021-05-08 | 14:30 | FC Dallas | 1.6 | 1–1 | 1.7 | Dynamo FC | 8,749 | Toyota Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-05-08 | 18:00 | Orlando City | 0.7 | 1–1 | 1.9 | NYCFC | 11,503 | Exploria Stadium | Robert Sibiga | Match Report | |
| Fri | 2021-05-07 | 19:30 | RSL | 1.1 | 1–2 | 2.0 | SJ Earthquakes | 10,448 | Rio Tinto Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-05-09 | 12:00 | Portland Timbers | 1.7 | 1–2 | 2.4 | Seattle | Providence Park | Chris Penso | Match Report | ||
| Sun | 2021-05-09 | 13:00 | Inter Miami | 2.2 | 1–1 | 1.3 | Atlanta Utd | 8,074 | DRV PNK Stadium | Joe Dickerson | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-05-08 | 17:00 | LA Galaxy | 1.0 | 2–1 | 1.2 | LAFC | 7,193 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Sun | 2021-05-09 | 18:30 | Sporting KC | 3.6 | 2–1 | 0.9 | Austin | Children's Mercy Park | Ted Unkel | Match Report | ||
| Sat | 2021-05-08 | 20:00 | Rapids | 1.2 | 3–2 | 1.3 | Minnesota Utd | Dick's Sporting Goods Park | Tim Ford | Match Report | ||
| Wed | 2021-05-12 | 19:00 | Toronto FC | 2.2 | 2–0 | 0.7 | Crew | Exploria Stadium | Fotis Bazakos | Match Report | ||
| Wed | 2021-05-12 | 19:30 | Inter Miami | 0.5 | 0–2 | 1.6 | CF Montréal | 8,220 | DRV PNK Stadium | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-05-12 | 19:30 | Philadelphia | 2.3 | 1–1 | 1.5 | NE Revolution | 5,000 | Subaru Park | Tori Penso | Match Report | |
| Wed | 2021-05-12 | 19:30 | Dynamo FC | 1.5 | 1–0 | 2.1 | Sporting KC | 7,054 | BBVA Stadium | Chris Penso | Match Report | |
| Wed | 2021-05-12 | 19:30 | SJ Earthquakes | 1.8 | 0–1 | 1.3 | Seattle | 5,000 | Earthquakes Stadium | Baldomero Toledo | Match Report | |
| Wed | 2021-05-12 | 20:00 | Minnesota Utd | 1.6 | 1–0 | 0.8 | Vancouver W'caps | 4,100 | Allianz Field | Jon Freemon | Match Report | |
| Thu | 2021-05-13 | 20:00 | D.C. United | 1.4 | 1–0 | 1.8 | Fire | 3,935 | Audi Field | Ramy Touchan | Match Report | |
| Sat | 2021-05-15 | 12:30 | LA Galaxy | 2.5 | 2–0 | 1.2 | Austin | 7,193 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Sat | 2021-05-15 | 13:00 | NYCFC | 1.6 | 1–1 | 0.6 | Toronto FC | Yankee Stadium | Dave Gantar | Match Report | ||
| Sat | 2021-05-15 | 19:00 | Atlanta Utd | 0.8 | 1–0 | 0.8 | CF Montréal | 40,116 | Mercedes-Benz Stadium | Silviu Petrescu | Match Report | |
| Sat | 2021-05-15 | 19:30 | Philadelphia | 1.0 | 1–0 | 1.1 | NY Red Bulls | 5,000 | Subaru Park | Allen Chapman | Match Report | |
| Sun | 2021-05-16 | 13:00 | Sporting KC | 3.2 | 3–0 | 1.1 | Vancouver W'caps | Children's Mercy Park | Alan Kelly | Match Report | ||
| Sun | 2021-05-16 | 16:00 | FC Cincinnati | 1.2 | 2–3 | 1.9 | Inter Miami | 6,000 | TQL Stadium | Ramy Touchan | Match Report | |
| Sun | 2021-05-16 | 18:00 | NE Revolution | 1.4 | 1–0 | 0.3 | Crew | Gillette Stadium | Robert Sibiga | Match Report | ||
| Sat | 2021-05-15 | 19:00 | Minnesota Utd | 2.1 | 1–0 | 1.0 | FC Dallas | 4,100 | Allianz Field | Ted Unkel | Match Report | |
| Sat | 2021-05-15 | 19:00 | SJ Earthquakes | 2.7 | 0–2 | 2.1 | Portland Timbers | Earthquakes Stadium | Tim Ford | Match Report | ||
| Sat | 2021-05-15 | 19:00 | Rapids | 2.2 | 3–1 | 0.4 | Dynamo FC | Dick's Sporting Goods Park | Victor Rivas | Match Report | ||
| Sat | 2021-05-15 | 19:30 | RSL | 0.8 | 0–0 | 1.0 | Nashville | 10,555 | Rio Tinto Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2021-05-16 | 18:30 | Seattle | 1.3 | 2–0 | 0.6 | LAFC | 7,173 | Lumen Field | Joe Dickerson | Match Report | |
| Sun | 2021-05-16 | 20:00 | D.C. United | 0.9 | 0–1 | 0.6 | Orlando City | 5,280 | Audi Field | Alex Chilowicz | Match Report | |
| Sat | 2021-05-22 | 12:30 | Portland Timbers | 3.3 | 3–0 | 1.2 | LA Galaxy | Providence Park | Alan Kelly | Match Report | ||
| Sat | 2021-05-22 | 13:00 | CF Montréal | 2.6 | 1–2 | 1.5 | FC Cincinnati | DRV PNK Stadium | Fotis Bazakos | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-05-22 | 17:00 | Fire | 1.9 | 1–0 | 0.3 | Inter Miami | 10,844 | Soldier Field | Silviu Petrescu | Match Report | |
| Sat | 2021-05-22 | 19:00 | Orlando City | 1.9 | 1–0 | 1.5 | Toronto FC | 11,525 | Exploria Stadium | Victor Rivas | Match Report | |
| Sat | 2021-05-22 | 19:30 | NYCFC | 1.4 | 1–2 | 0.6 | Crew | 3,154 | Red Bull Arena | Drew Fischer | Match Report | |
| Sun | 2021-05-23 | 13:30 | Seattle | 0.5 | 1–1 | 1.1 | Atlanta Utd | 11,011 | Lumen Field | Kevin Stott | Match Report | |
| Sat | 2021-05-22 | 19:00 | SJ Earthquakes | 1.8 | 1–3 | 1.7 | Sporting KC | Earthquakes Stadium | Allen Chapman | Match Report | ||
| Sat | 2021-05-22 | 19:00 | FC Dallas | 2.9 | 2–2 | 1.1 | RSL | 8,621 | Toyota Stadium | Joe Dickerson | Match Report | |
| Sun | 2021-05-23 | 19:15 | D.C. United | 1.2 | 0–1 | 1.2 | Philadelphia | 6,200 | Audi Field | Tim Ford | Match Report | |
| Sat | 2021-05-22 | 19:30 | LAFC | 1.5 | 2–1 | 1.1 | Rapids | 10,483 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-05-22 | 20:00 | Dynamo FC | 1.4 | 2–1 | 1.3 | Vancouver W'caps | 9,255 | BBVA Stadium | Dave Gantar | Match Report | |
| Sat | 2021-05-22 | 20:00 | NE Revolution | 3.7 | 3–1 | 1.2 | NY Red Bulls | Gillette Stadium | Jair Marrufo | Match Report | ||
| Sun | 2021-05-23 | 20:00 | Nashville | 2.3 | 1–0 | 0.7 | Austin | 22,421 | Nissan Stadium | Chris Penso | Match Report | |
| Sat | 2021-05-29 | 12:00 | Fire | 2.0 | 0–1 | 0.6 | CF Montréal | 6,680 | Soldier Field | Victor Rivas | Match Report | |
| Sat | 2021-05-29 | 13:00 | NY Red Bulls | 1.7 | 2–1 | 1.2 | Orlando City | Red Bull Arena | Ismail Elfath | Match Report | ||
| Sat | 2021-05-29 | 14:00 | LAFC | 2.3 | 1–2 | 1.0 | NYCFC | 10,703 | Banc of California Stadium | Kevin Stott | Match Report | |
| Sat | 2021-05-29 | 15:00 | FC Cincinnati | 0.8 | 0–1 | 1.9 | NE Revolution | 11,000 | TQL Stadium | Dave Gantar | Match Report | |
| Sat | 2021-05-29 | 15:00 | Crew | 1.1 | 2–1 | 1.0 | Toronto FC | 5,700 | MAPFRE Stadium | Allen Chapman | Match Report | |
| Sat | 2021-05-29 | 15:30 | Atlanta Utd | 1.5 | 2–2 | 1.8 | Nashville | 40,748 | Mercedes-Benz Stadium | Alan Kelly | Match Report | |
| Sat | 2021-05-29 | 16:00 | LA Galaxy | 1.6 | 1–0 | 1.9 | SJ Earthquakes | Dignity Health Sports Park | Joe Dickerson | Match Report | ||
| Sat | 2021-05-29 | 19:00 | Rapids | 1.9 | 3–0 | 1.9 | FC Dallas | Dick's Sporting Goods Park | Guido Gonzalez Jr. | Match Report | ||
| Sun | 2021-05-30 | 19:00 | Philadelphia | 2.8 | 3–0 | 1.2 | Portland Timbers | 6,635 | Subaru Park | Robert Sibiga | Match Report | |
| Sat | 2021-05-29 | 19:30 | RSL | 1.1 | 1–1 | 0.9 | Minnesota Utd | 10,853 | Rio Tinto Stadium | Jair Marrufo | Match Report | |
| Sat | 2021-05-29 | 19:30 | Sporting KC | 2.3 | 3–2 | 2.1 | Dynamo FC | 20,086 | Children's Mercy Park | Drew Fischer | Match Report | |
| Sat | 2021-05-29 | 20:00 | Inter Miami | 0.7 | 0–3 | 2.2 | D.C. United | DRV PNK Stadium | Armando Villarreal | Match Report | ||
| Sun | 2021-05-30 | 18:30 | Seattle | 1.0 | 0–0 | 0.9 | Austin | 12,895 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2021-06-12 | 14:00 | Sporting KC | 2.9 | 1–1 | 1.9 | Austin | 18,519 | Children's Mercy Park | Robert Sibiga | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-06-19 | 19:30 | Crew | 2.2 | 2–0 | 1.0 | Fire | 20,064 | MAPFRE Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-06-19 | 19:30 | NYCFC | 3.2 | 2–3 | 1.1 | NE Revolution | 4,929 | Red Bull Arena | Allen Chapman | Match Report | |
| Sat | 2021-06-19 | 19:30 | Toronto FC | 2.4 | 2–3 | 1.3 | Orlando City | Exploria Stadium | Armando Villarreal | Match Report | ||
| Sat | 2021-06-19 | 19:30 | FC Cincinnati | 2.2 | 0–2 | 0.8 | Rapids | 25,054 | TQL Stadium | Baldomero Toledo | Match Report | |
| Fri | 2021-06-18 | 20:00 | RSL | 1.5 | 3–1 | 1.4 | Vancouver W'caps | 15,109 | Rio Tinto Stadium | Rubiel Vazquez | Match Report | |
| Fri | 2021-06-18 | 20:00 | NY Red Bulls | 1.1 | 2–0 | 0.8 | Nashville | 10,173 | Red Bull Arena | Nima Saghafi | Match Report | |
| Sun | 2021-06-20 | 14:00 | Atlanta Utd | 1.4 | 2–2 | 1.6 | Philadelphia | 42,523 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Sat | 2021-06-19 | 18:00 | LA Galaxy | 1.4 | 1–2 | 1.6 | Seattle | 23,165 | Dignity Health Sports Park | Drew Fischer | Match Report | |
| Sat | 2021-06-19 | 19:30 | FC Dallas | 1.0 | 1–1 | 2.1 | Minnesota Utd | 16,455 | Toyota Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-06-19 | 19:30 | Portland Timbers | 1.3 | 2–1 | 1.9 | Sporting KC | Providence Park | Alan Kelly | Match Report | ||
| Sat | 2021-06-19 | 20:00 | Austin | 1.7 | 0–0 | 0.8 | SJ Earthquakes | Q2 Stadium | Ismail Elfath | Match Report | ||
| Sat | 2021-06-19 | 20:00 | D.C. United | 2.8 | 1–0 | 1.0 | Inter Miami | 16 | Audi Field | Fotis Bazakos | Match Report | |
| Sat | 2021-06-19 | 20:00 | LAFC | 1.9 | 1–1 | 0.5 | Dynamo FC | 22,043 | Banc of California Stadium | Joe Dickerson | Match Report | |
| Tue | 2021-06-22 | 19:30 | Orlando City | 3.0 | 5–0 | 0.7 | SJ Earthquakes | 15,476 | Exploria Stadium | Chris Penso | Match Report | |
| Wed | 2021-06-23 | 19:00 | NE Revolution | 1.6 | 3–2 | 1.5 | NY Red Bulls | Gillette Stadium | Robert Sibiga | Match Report | ||
| Wed | 2021-06-23 | 19:30 | NYCFC | 2.2 | 1–0 | 0.3 | Atlanta Utd | 3,564 | Red Bull Arena | Ismail Elfath | Match Report | |
| Wed | 2021-06-23 | 19:30 | Philadelphia | 0.5 | 1–0 | 0.5 | Crew | 16,234 | Subaru Park | Joe Dickerson | Match Report | |
| Wed | 2021-06-23 | 19:00 | Fire | 2.1 | 0–1 | 1.9 | FC Cincinnati | 5,926 | Soldier Field | Ismir Pekmic | Match Report | |
| Wed | 2021-06-23 | 19:00 | Seattle | 2.4 | 2–1 | 1.2 | RSL | 24,652 | Lumen Field | Ted Unkel | Match Report | |
| Wed | 2021-06-23 | 19:00 | Minnesota Utd | 1.4 | 2–0 | 1.0 | Austin | 19,209 | Allianz Field | Silviu Petrescu | Match Report | |
| Wed | 2021-06-23 | 19:30 | Sporting KC | 2.5 | 3–1 | 1.5 | Rapids | 18,690 | Children's Mercy Park | Dave Gantar | Match Report | |
| Wed | 2021-06-23 | 19:30 | LAFC | 3.1 | 2–0 | 0.8 | FC Dallas | 22,510 | Banc of California Stadium | Rosendo Mendoza | Match Report | |
| Wed | 2021-06-23 | 19:30 | Nashville | 2.4 | 3–2 | 1.7 | Toronto FC | 17,008 | Nissan Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-06-23 | 19:30 | Dynamo FC | 1.9 | 2–2 | 1.6 | Portland Timbers | 10,791 | BBVA Stadium | Armando Villarreal | Match Report | |
| Wed | 2021-06-23 | 20:00 | CF Montréal | 0.2 | 0–0 | 2.8 | D.C. United | DRV PNK Stadium | Drew Fischer | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-06-23 | 20:30 | Vancouver W'caps | 1.2 | 1–2 | 1.0 | LA Galaxy | Rio Tinto Stadium | Tori Penso | Match Report | ||
| Sat | 2021-06-26 | 16:30 | Sporting KC | 1.4 | 2–1 | 0.8 | LAFC | 20,213 | Children's Mercy Park | Chris Penso | Match Report | |
| Sat | 2021-06-26 | 19:00 | Toronto FC | 0.5 | 0–2 | 1.4 | FC Cincinnati | Exploria Stadium | Rubiel Vazquez | Match Report | ||
| Fri | 2021-06-25 | 20:00 | Inter Miami | 0.9 | 1–2 | 0.7 | Orlando City | 17,926 | DRV PNK Stadium | Allen Chapman | Match Report | |
| Sun | 2021-06-27 | 15:30 | Atlanta Utd | 1.6 | 0–0 | 0.7 | NY Red Bulls | 42,575 | Mercedes-Benz Stadium | Alan Kelly | Match Report | |
| Sat | 2021-06-26 | 18:00 | Seattle | 2.5 | 2–2 | 1.6 | Vancouver W'caps | 25,603 | Lumen Field | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-06-27 | 18:00 | NYCFC | 1.5 | 2–1 | 0.9 | D.C. United | 4,533 | Red Bull Arena | Robert Sibiga | Match Report | |
| Sat | 2021-06-26 | 18:00 | RSL | 2.8 | 1–1 | 1.0 | Dynamo FC | 13,588 | Rio Tinto Stadium | Nima Saghafi | Match Report | |
| Sat | 2021-06-26 | 19:00 | SJ Earthquakes | 0.9 | 1–3 | 2.1 | LA Galaxy | 18,000 | Stanford Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-06-26 | 19:00 | Fire | 1.3 | 3–3 | 1.5 | Philadelphia | 7,308 | Soldier Field | Fotis Bazakos | Match Report | |
| Sat | 2021-06-26 | 19:30 | Nashville | 2.1 | 1–1 | 0.6 | CF Montréal | 22,523 | Nissan Stadium | Jon Freemon | Match Report | |
| Sat | 2021-06-26 | 20:30 | Portland Timbers | 1.8 | 0–1 | 2.6 | Minnesota Utd | Providence Park | Rosendo Mendoza | Match Report | ||
| Sun | 2021-06-27 | 19:00 | Austin | 1.4 | 0–0 | 1.1 | Crew | 20,738 | Q2 Stadium | Ted Unkel | Match Report | |
| Sun | 2021-06-27 | 20:00 | FC Dallas | 0.9 | 2–1 | 1.3 | NE Revolution | 14,889 | Toyota Stadium | Kevin Stott | Match Report | |
| Thu | 2021-07-01 | 20:30 | Austin | 1.7 | 4–1 | 0.6 | Portland Timbers | 20,738 | Q2 Stadium | Ted Unkel | Match Report | |
| Sat | 2021-07-03 | 17:00 | Crew | 1.3 | 2–2 | 1.4 | NE Revolution | 20,407 | Lower.com Field | Alan Kelly | Match Report | |
| Sat | 2021-07-03 | 17:30 | D.C. United | 3.1 | 7–1 | 1.2 | Toronto FC | 14,000 | Audi Field | Lukasz Szpala | Match Report | |
| Sat | 2021-07-03 | 19:30 | CF Montréal | 1.9 | 1–0 | 0.3 | Inter Miami | Red Bull Arena | Rosendo Mendoza | Match Report | ||
| Sat | 2021-07-03 | 19:30 | Orlando City | 1.7 | 1–2 | 1.9 | NY Red Bulls | 19,009 | Exploria Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-07-03 | 19:00 | Minnesota Utd | 2.8 | 2–2 | 0.8 | SJ Earthquakes | 19,687 | Allianz Field | Michael Radchuk | Match Report | |
| Sat | 2021-07-03 | 19:00 | Fire | 1.5 | 3–0 | 1.0 | Atlanta Utd | 14,898 | Soldier Field | Baldomero Toledo | Match Report | |
| Sat | 2021-07-03 | 19:00 | Nashville | 1.3 | 1–0 | 0.9 | Philadelphia | 21,822 | Nissan Stadium | Robert Sibiga | Match Report | |
| Sat | 2021-07-03 | 19:30 | Dynamo FC | 1.8 | 1–1 | 1.5 | FC Cincinnati | 20,021 | BBVA Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-03 | 20:00 | RSL | 1.3 | 0–1 | 0.6 | LAFC | 18,253 | Rio Tinto Stadium | Silviu Petrescu | Match Report | |
| Sun | 2021-07-04 | 19:00 | Rapids | 1.1 | 1–1 | 0.9 | Seattle | 17,104 | Dick's Sporting Goods Park | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-07-04 | 19:30 | LA Galaxy | 1.6 | 0–2 | 2.2 | Sporting KC | 23,556 | Dignity Health Sports Park | Alex Chilowicz | Match Report | |
| Sun | 2021-07-04 | 19:30 | FC Dallas | 1.6 | 2–2 | 1.0 | Vancouver W'caps | 19,096 | Toyota Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-07-07 | 19:00 | NE Revolution | 2.8 | 2–3 | 1.9 | Toronto FC | Gillette Stadium | Rosendo Mendoza | Match Report | ||
| Wed | 2021-07-07 | 19:30 | CF Montréal | 2.3 | 2–1 | 0.6 | NYCFC | Exploria Stadium | Marcos de Oliveira | Match Report | ||
| Wed | 2021-07-07 | 18:00 | Seattle | 2.2 | 2–0 | 0.8 | Dynamo FC | 27,421 | Lumen Field | Robert Sibiga | Match Report | |
| Wed | 2021-07-07 | 19:00 | Rapids | 1.6 | 2–0 | 0.7 | Minnesota Utd | Dick's Sporting Goods Park | Ted Unkel | Match Report | ||
| Wed | 2021-07-07 | 19:00 | Fire | 1.6 | 3–1 | 2.6 | Orlando City | 8,002 | Soldier Field | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-07-07 | 19:30 | LA Galaxy | 1.4 | 3–1 | 1.8 | FC Dallas | 16,453 | Dignity Health Sports Park | Alan Kelly | Match Report | |
| Wed | 2021-07-07 | 20:00 | Austin | 0.7 | 0–2 | 2.0 | LAFC | 20,738 | Q2 Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-07-07 | 20:00 | Vancouver W'caps | 1.1 | 0–4 | 3.1 | RSL | 12,009 | Rio Tinto Stadium | Alex Chilowicz | Match Report | |
| Thu | 2021-07-08 | 19:30 | Nashville | 2.1 | 2–2 | 0.6 | Atlanta Utd | 22,913 | Nissan Stadium | Joe Dickerson | Match Report | |
| Fri | 2021-07-09 | 19:30 | FC Cincinnati | 0.9 | 2–2 | 1.0 | Crew | 25,701 | TQL Stadium | Kevin Stott | Match Report | |
| Thu | 2021-07-08 | 20:00 | NY Red Bulls | 2.1 | 1–1 | 0.9 | Philadelphia | 10,013 | Red Bull Arena | Victor Rivas | Match Report | |
| Sat | 2021-07-17 | 17:00 | Atlanta Utd | 0.7 | 0–1 | 1.3 | NE Revolution | 42,517 | Mercedes-Benz Stadium | Victor Rivas | Match Report | |
| Sat | 2021-07-17 | 19:30 | CF Montréal | 2.9 | 5–4 | 1.3 | FC Cincinnati | Stade Saputo | Silviu Petrescu | Match Report | ||
| Sat | 2021-07-17 | 19:30 | Philadelphia | 1.2 | 2–1 | 1.4 | D.C. United | 16,821 | Subaru Park | Alex Chilowicz | Match Report | |
| Sat | 2021-07-17 | 19:30 | Toronto FC | 0.7 | 1–1 | 1.3 | Orlando City | 7,000 | BMO Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-17 | 19:30 | Crew | 0.8 | 2–1 | 1.8 | NYCFC | 19,113 | Lower.com Field | Ramy Touchan | Match Report | |
| Sun | 2021-07-18 | 13:00 | Minnesota Utd | 1.7 | 1–0 | 0.7 | Seattle | 19,679 | Allianz Field | Alan Kelly | Match Report | |
| Sat | 2021-07-17 | 19:00 | Rapids | 0.8 | 1–1 | 0.4 | SJ Earthquakes | 14,664 | Dick's Sporting Goods Park | Rosendo Mendoza | Match Report | |
| Sat | 2021-07-17 | 19:30 | LAFC | 4.8 | 2–1 | 0.9 | RSL | 22,490 | Banc of California Stadium | Robert Sibiga | Match Report | |
| Sat | 2021-07-17 | 19:30 | Portland Timbers | 1.0 | 1–0 | 0.8 | FC Dallas | 23,255 | Providence Park | Joe Dickerson | Match Report | |
| Sat | 2021-07-17 | 19:30 | Nashville | 3.4 | 5–1 | 1.9 | Fire | 23,113 | Nissan Stadium | Lukasz Szpala | Match Report | |
| Sat | 2021-07-17 | 20:00 | Vancouver W'caps | 1.5 | 2–1 | 0.8 | LA Galaxy | Rio Tinto Stadium | Ismir Pekmic | Match Report | ||
| Wed | 2021-07-21 | 19:30 | NYCFC | 1.9 | 1–0 | 0.5 | CF Montréal | 2,873 | Red Bull Arena | Ted Unkel | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-07-21 | 19:30 | Crew | 1.6 | 0–0 | 0.6 | Nashville | 18,395 | Lower.com Field | Rosendo Mendoza | Match Report | |
| Wed | 2021-07-21 | 19:30 | Toronto FC | 0.3 | 1–1 | 2.0 | NY Red Bulls | BMO Field | Silviu Petrescu | Match Report | ||
| Wed | 2021-07-21 | 19:30 | Inter Miami | 1.2 | 0–5 | 3.3 | NE Revolution | 13,963 | DRV PNK Stadium | Robert Sibiga | Match Report | |
| Tue | 2021-07-20 | 20:00 | Vancouver W'caps | 0.7 | 0–0 | 0.3 | Dynamo FC | Rio Tinto Stadium | Guido Gonzalez Jr. | Match Report | ||
| Wed | 2021-07-21 | 19:00 | Fire | 0.6 | 2–2 | 2.2 | D.C. United | 8,306 | Soldier Field | Marcos de Oliveira | Match Report | |
| Wed | 2021-07-21 | 19:00 | Rapids | 0.7 | 2–0 | 0.7 | FC Dallas | 8,321 | Dick's Sporting Goods Park | Jon Freemon | Match Report | |
| Wed | 2021-07-21 | 19:30 | Sporting KC | 2.2 | 1–1 | 1.6 | SJ Earthquakes | 17,872 | Children's Mercy Park | Joe Dickerson | Match Report | |
| Wed | 2021-07-21 | 19:30 | Portland Timbers | 0.6 | 2–1 | 2.2 | LAFC | 23,500 | Providence Park | Victor Rivas | Match Report | |
| Thu | 2021-07-22 | 19:30 | Orlando City | 0.9 | 2–1 | 1.3 | Philadelphia | 15,432 | Exploria Stadium | Alan Kelly | Match Report | |
| Wed | 2021-07-21 | 20:00 | FC Cincinnati | 1.0 | 1–1 | 1.9 | Atlanta Utd | 23,162 | TQL Stadium | Tori Penso | Match Report | |
| Wed | 2021-07-21 | 20:00 | RSL | 1.4 | 2–2 | 1.4 | LA Galaxy | 16,169 | Rio Tinto Stadium | Kevin Stott | Match Report | |
| Thu | 2021-07-22 | 20:30 | Austin | 0.9 | 0–1 | 0.6 | Seattle | 20,738 | Q2 Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-07-24 | 15:30 | Atlanta Utd | 1.8 | 0–1 | 1.7 | Crew | 67,507 | Mercedes-Benz Stadium | Robert Sibiga | Match Report | |
| Sun | 2021-07-25 | 18:00 | NE Revolution | 1.4 | 2–1 | 1.8 | CF Montréal | 18,217 | Gillette Stadium | Alex Chilowicz | Match Report | |
| Sun | 2021-07-25 | 18:00 | NYCFC | 3.9 | 5–0 | 0.6 | Orlando City | 13,503 | Yankee Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-07-24 | 19:00 | SJ Earthquakes | 1.1 | 1–1 | 0.7 | Dynamo FC | 12,793 | Earthquakes Stadium | Ted Unkel | Match Report | |
| Sat | 2021-07-24 | 19:00 | Minnesota Utd | 2.2 | 2–1 | 0.4 | Portland Timbers | 19,691 | Allianz Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-24 | 19:00 | Fire | 3.9 | 1–2 | 0.8 | Toronto FC | 12,288 | Soldier Field | Victor Rivas | Match Report | |
| Sun | 2021-07-25 | 19:30 | Inter Miami | 1.1 | 1–1 | 1.6 | Philadelphia | 14,057 | DRV PNK Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-07-24 | 19:30 | LAFC | 1.0 | 2–2 | 1.2 | Vancouver W'caps | 22,049 | Banc of California Stadium | Kevin Stott | Match Report | |
| Sat | 2021-07-24 | 19:30 | FC Dallas | 1.7 | 4–0 | 1.4 | LA Galaxy | 14,812 | Toyota Stadium | Silviu Petrescu | Match Report | |
| Sat | 2021-07-24 | 19:30 | Nashville | 0.9 | 3–0 | 0.5 | FC Cincinnati | 23,832 | Nissan Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-07-24 | 20:00 | RSL | 1.0 | 3–0 | 0.5 | Rapids | 17,325 | Rio Tinto Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-07-25 | 18:00 | Seattle | 0.9 | 1–3 | 1.1 | Sporting KC | 32,790 | Lumen Field | Ramy Touchan | Match Report | |
| Sun | 2021-07-25 | 20:00 | D.C. United | 1.1 | 1–0 | 0.2 | NY Red Bulls | 15,912 | Audi Field | Alan Kelly | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-07-28 | 19:30 | LAFC | 2.2 | 2–2 | 1.1 | Minnesota Utd | 22,003 | Banc of California Stadium | Baldomero Toledo | Match Report | |
| Fri | 2021-07-30 | 19:30 | NYCFC | 3.3 | 4–1 | 1.5 | Crew | Yankee Stadium | Alan Kelly | Match Report | ||
| Sat | 2021-07-31 | 14:00 | Seattle | 1.0 | 0–1 | 0.6 | SJ Earthquakes | 32,704 | Lumen Field | Joe Dickerson | Match Report | |
| Sat | 2021-07-31 | 18:00 | NY Red Bulls | 1.3 | 2–3 | 2.5 | NE Revolution | 13,444 | Red Bull Arena | Ramy Touchan | Match Report | |
| Fri | 2021-07-30 | 19:00 | LA Galaxy | 3.0 | 4–1 | 1.0 | Portland Timbers | 15,644 | Dignity Health Sports Park | Robert Sibiga | Match Report | |
| Sat | 2021-07-31 | 19:30 | FC Cincinnati | 1.7 | 0–0 | 0.5 | D.C. United | 25,060 | TQL Stadium | Rosendo Mendoza | Match Report | |
| Fri | 2021-07-30 | 20:00 | Orlando City | 2.6 | 3–2 | 0.5 | Atlanta Utd | 18,910 | Exploria Stadium | Rubiel Vazquez | Match Report | |
| Sun | 2021-08-01 | 18:00 | Philadelphia | 2.6 | 1–1 | 0.3 | Fire | 16,677 | Subaru Park | Michael Radchuk | Match Report | |
| Sat | 2021-07-31 | 19:30 | Sporting KC | 1.7 | 1–2 | 1.1 | FC Dallas | 19,975 | Children's Mercy Park | Alex Chilowicz | Match Report | |
| Sat | 2021-07-31 | 19:30 | Dynamo FC | 1.4 | 0–0 | 1.4 | RSL | 13,462 | BBVA Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-08-01 | 19:30 | Toronto FC | 0.6 | 1–1 | 1.1 | Nashville | BMO Field | Fotis Bazakos | Match Report | ||
| Sat | 2021-07-31 | 20:00 | Austin | 0.9 | 0–1 | 2.3 | Rapids | 20,738 | Q2 Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-31 | 20:00 | Inter Miami | 2.0 | 2–1 | 1.6 | CF Montréal | 14,303 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sat | 2021-07-31 | 20:00 | Vancouver W'caps | 1.7 | 2–2 | 1.2 | Minnesota Utd | Rio Tinto Stadium | Lukasz Szpala | Match Report | ||
| Wed | 2021-08-04 | 19:00 | NE Revolution | 0.6 | 0–0 | 0.5 | Nashville | 10,279 | Gillette Stadium | Silviu Petrescu | Match Report | |
| Wed | 2021-08-04 | 19:30 | Crew | 1.5 | 2–4 | 1.7 | D.C. United | 18,398 | Lower.com Field | Victor Rivas | Match Report | |
| Wed | 2021-08-04 | 19:30 | Philadelphia | 2.6 | 3–0 | 1.4 | Toronto FC | 14,303 | Subaru Park | Ted Unkel | Match Report | |
| Wed | 2021-08-04 | 19:30 | CF Montréal | 1.6 | 2–2 | 1.8 | Atlanta Utd | 11,000 | Stade Saputo | Dave Gantar | Match Report | |
| Wed | 2021-08-04 | 19:00 | Seattle | 2.0 | 1–1 | 1.2 | FC Dallas | 31,628 | Lumen Field | Fotis Bazakos | Match Report | |
| Wed | 2021-08-04 | 19:00 | Fire | 0.3 | 0–0 | 1.4 | NYCFC | 8,371 | Soldier Field | Baldomero Toledo | Match Report | |
| Wed | 2021-08-04 | 19:30 | LAFC | 2.3 | 1–4 | 2.0 | Sporting KC | 22,114 | Banc of California Stadium | Alan Kelly | Match Report | |
| Wed | 2021-08-04 | 19:30 | LA Galaxy | 1.6 | 1–0 | 1.3 | RSL | 15,544 | Dignity Health Sports Park | Nima Saghafi | Match Report | |
| Wed | 2021-08-04 | 19:30 | Portland Timbers | 2.1 | 1–1 | 2.4 | SJ Earthquakes | 22,233 | Providence Park | Allen Chapman | Match Report | |
| Wed | 2021-08-04 | 20:00 | Orlando City | 1.0 | 1–1 | 0.2 | Inter Miami | 17,966 | Exploria Stadium | Armando Villarreal | Match Report | |
| Wed | 2021-08-04 | 20:00 | NY Red Bulls | 2.2 | 0–0 | 0.5 | FC Cincinnati | 9,203 | Red Bull Arena | Jon Freemon | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-08-04 | 20:00 | Austin | 1.4 | 3–2 | 0.8 | Dynamo FC | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-08-07 | 19:30 | Crew | 1.7 | 2–3 | 2.7 | Atlanta Utd | 20,094 | Lower.com Field | Allen Chapman | Match Report | |
| Sat | 2021-08-07 | 19:30 | FC Cincinnati | 1.2 | 1–1 | 1.2 | Orlando City | 24,113 | TQL Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-08-08 | 16:00 | SJ Earthquakes | 1.8 | 2–1 | 1.6 | LAFC | 18,000 | Earthquakes Stadium | Rubiel Vazquez | Match Report | |
| Sun | 2021-08-08 | 17:00 | Fire | 1.1 | 2–1 | 1.3 | NY Red Bulls | 11,894 | Soldier Field | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-08-08 | 18:00 | Inter Miami | 1.5 | 2–1 | 0.6 | Nashville | 14,062 | DRV PNK Stadium | Nima Saghafi | Match Report | |
| Sun | 2021-08-08 | 18:00 | NE Revolution | 2.3 | 2–1 | 2.1 | Philadelphia | 17,054 | Gillette Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-08-07 | 19:00 | Minnesota Utd | 1.2 | 2–0 | 0.6 | Dynamo FC | 19,625 | Allianz Field | Silviu Petrescu | Match Report | |
| Sat | 2021-08-07 | 19:00 | Rapids | 2.3 | 0–0 | 0.7 | Sporting KC | 11,753 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2021-08-07 | 19:30 | Portland Timbers | 1.8 | 3–2 | 2.6 | RSL | 23,577 | Providence Park | Rosendo Mendoza | Match Report | |
| Sat | 2021-08-07 | 19:30 | FC Dallas | 1.1 | 2–0 | 1.2 | Austin | 16,625 | Toyota Stadium | Alan Kelly | Match Report | |
| Sat | 2021-08-07 | 20:00 | Toronto FC | 2.5 | 2–2 | 1.3 | NYCFC | 9,331 | BMO Field | Robert Sibiga | Match Report | |
| Sun | 2021-08-08 | 17:00 | LA Galaxy | 1.6 | 1–1 | 1.0 | Vancouver W'caps | 16,234 | Dignity Health Sports Park | Baldomero Toledo | Match Report | |
| Sun | 2021-08-08 | 20:00 | D.C. United | 1.6 | 2–1 | 1.0 | CF Montréal | 14,169 | Audi Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-08-14 | 17:00 | Minnesota Utd | 2.0 | 0–1 | 1.6 | LA Galaxy | 19,787 | Allianz Field | Joe Dickerson | Match Report | |
| Fri | 2021-08-13 | 19:30 | SJ Earthquakes | 1.0 | 0–0 | 1.0 | Vancouver W'caps | 11,967 | Earthquakes Stadium | Tim Ford | Match Report | |
| Sun | 2021-08-15 | 16:00 | Atlanta Utd | 1.1 | 1–0 | 1.2 | LAFC | 67,503 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sun | 2021-08-15 | 17:00 | Fire | 1.5 | 1–0 | 0.8 | Crew | 13,005 | Soldier Field | Nima Saghafi | Match Report | |
| Sun | 2021-08-15 | 18:00 | Nashville | 2.1 | 5–2 | 0.9 | D.C. United | 20,022 | Nissan Stadium | Drew Fischer | Match Report | |
| Sat | 2021-08-14 | 19:30 | FC Dallas | 1.7 | 0–2 | 0.9 | Sporting KC | 14,133 | Toyota Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-08-14 | 19:30 | Dynamo FC | 2.7 | 1–3 | 1.8 | Rapids | 13,908 | BBVA Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-08-14 | 20:00 | Toronto FC | 1.1 | 1–2 | 1.3 | NE Revolution | BMO Field | Rubiel Vazquez | Match Report | ||
| Sat | 2021-08-14 | 20:00 | CF Montréal | 2.9 | 2–1 | 1.7 | NY Red Bulls | Stade Saputo | Allen Chapman | Match Report | ||
| Sat | 2021-08-14 | 20:00 | RSL | 1.5 | 1–0 | 1.1 | Austin | 17,506 | Rio Tinto Stadium | Dave Gantar | Match Report | |
| Sat | 2021-08-14 | 20:00 | NYCFC | 2.2 | 2–0 | 0.3 | Inter Miami | Red Bull Arena | Alex Chilowicz | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-08-15 | 19:00 | Portland Timbers | 1.8 | 2–6 | 2.4 | Seattle | 25,218 | Providence Park | Jair Marrufo | Match Report | |
| Wed | 2021-08-18 | 19:00 | Atlanta Utd | 1.8 | 1–0 | 1.3 | Toronto FC | 42,502 | Mercedes-Benz Stadium | Alan Kelly | Match Report | |
| Wed | 2021-08-18 | 19:00 | NE Revolution | 1.9 | 3–2 | 2.2 | D.C. United | 11,419 | Gillette Stadium | Ted Unkel | Match Report | |
| Tue | 2021-08-17 | 19:30 | LA Galaxy | 1.4 | 1–2 | 2.1 | Rapids | 15,101 | Dignity Health Sports Park | Silviu Petrescu | Match Report | |
| Wed | 2021-08-18 | 19:30 | FC Cincinnati | 0.9 | 0–0 | 0.4 | CF Montréal | 21,115 | TQL Stadium | Ramy Touchan | Match Report | |
| Tue | 2021-08-17 | 19:30 | SJ Earthquakes | 0.2 | 1–1 | 1.5 | Minnesota Utd | 10,353 | Earthquakes Stadium | Victor Rivas | Match Report | |
| Wed | 2021-08-18 | 19:30 | Inter Miami | 1.9 | 3–2 | 1.3 | Fire | 13,196 | DRV PNK Stadium | Baldomero Toledo | Match Report | |
| Wed | 2021-08-18 | 19:30 | Philadelphia | 0.7 | 1–0 | 1.3 | NYCFC | 15,263 | Subaru Park | Drew Fischer | Match Report | |
| Wed | 2021-08-18 | 19:30 | Nashville | 1.1 | 1–1 | 0.8 | Orlando City | 13,154 | Nissan Stadium | Fotis Bazakos | Match Report | |
| Wed | 2021-08-18 | 19:30 | Sporting KC | 2.1 | 1–1 | 1.3 | Portland Timbers | 17,081 | Children's Mercy Park | Ismail Elfath | Match Report | |
| Wed | 2021-08-18 | 19:30 | FC Dallas | 1.4 | 0–1 | 0.7 | Seattle | 11,535 | Toyota Stadium | Robert Sibiga | Match Report | |
| Wed | 2021-08-18 | 20:00 | RSL | 1.0 | 2–1 | 1.4 | Dynamo FC | 13,570 | Rio Tinto Stadium | Jair Marrufo | Match Report | |
| Wed | 2021-08-18 | 20:00 | Austin | 0.9 | 1–2 | 2.3 | Vancouver W'caps | 20,738 | Q2 Stadium | Rosendo Mendoza | Match Report | |
| Wed | 2021-08-18 | 20:00 | NY Red Bulls | 1.0 | 1–0 | 1.4 | Crew | 10,002 | Red Bull Arena | Chris Penso | Match Report | |
| Sat | 2021-08-21 | 14:30 | Minnesota Utd | 3.0 | 0–0 | 0.9 | Sporting KC | Allianz Field | Marcos de Oliveira | Match Report | ||
| Sat | 2021-08-21 | 17:30 | Crew | 0.9 | 1–2 | 1.6 | Seattle | 19,401 | Lower.com Field | Joe Dickerson | Match Report | |
| Fri | 2021-08-20 | 19:30 | LA Galaxy | 1.3 | 1–2 | 1.7 | SJ Earthquakes | 17,568 | Dignity Health Sports Park | Armando Villarreal | Match Report | |
| Sat | 2021-08-21 | 19:00 | Rapids | 1.7 | 2–1 | 1.9 | RSL | 13,134 | Dick's Sporting Goods Park | Drew Fischer | Match Report | |
| Sat | 2021-08-21 | 19:00 | Vancouver W'caps | 1.5 | 2–1 | 3.9 | LAFC | BC Place Stadium | Alex Chilowicz | Match Report | ||
| Sat | 2021-08-21 | 19:30 | Dynamo FC | 2.3 | 2–2 | 0.9 | FC Dallas | 13,548 | BBVA Stadium | Allen Chapman | Match Report | |
| Sat | 2021-08-21 | 20:00 | Austin | 3.0 | 3–1 | 1.0 | Portland Timbers | 20,738 | Q2 Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-08-21 | 20:00 | NE Revolution | 1.8 | 4–1 | 0.9 | FC Cincinnati | 18,268 | Gillette Stadium | Fotis Bazakos | Match Report | |
| Sat | 2021-08-21 | 20:00 | D.C. United | 2.3 | 1–2 | 1.4 | Atlanta Utd | 17,180 | Audi Field | Nima Saghafi | Match Report | |
| Sat | 2021-08-21 | 20:00 | Philadelphia | 1.2 | 1–1 | 1.3 | CF Montréal | 14,794 | Subaru Park | Chris Penso | Match Report | |
| Sat | 2021-08-21 | 20:00 | Orlando City | 0.9 | 1–0 | 1.4 | Fire | 15,538 | Exploria Stadium | Tim Ford | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-08-21 | 20:00 | Inter Miami | 2.8 | 3–1 | 0.8 | Toronto FC | 14,897 | DRV PNK Stadium | Jair Marrufo | Match Report | |
| Fri | 2021-08-27 | 18:30 | Crew | 2.6 | 3–2 | 1.6 | FC Cincinnati | 19,949 | Lower.com Field | Robert Sibiga | Match Report | |
| Fri | 2021-08-27 | 19:30 | CF Montréal | 2.7 | 3–1 | 0.5 | Toronto FC | Stade Saputo | Drew Fischer | Match Report | ||
| Sat | 2021-08-28 | 15:30 | Atlanta Utd | 0.6 | 0–2 | 1.9 | Nashville | 42,506 | Mercedes-Benz Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-08-28 | 16:00 | LAFC | 2.9 | 3–3 | 1.3 | LA Galaxy | 22,032 | Banc of California Stadium | Allen Chapman | Match Report | |
| Sat | 2021-08-28 | 18:00 | NY Red Bulls | 1.4 | 0–1 | 1.0 | Fire | 12,018 | Red Bull Arena | Victor Rivas | Match Report | |
| Sat | 2021-08-28 | 19:30 | NYCFC | 1.9 | 2–0 | 1.3 | NE Revolution | Yankee Stadium | Kevin Stott | Match Report | ||
| Fri | 2021-08-27 | 20:30 | Orlando City | 2.1 | 0–0 | 0.8 | Inter Miami | 17,817 | Exploria Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-08-28 | 20:00 | D.C. United | 2.8 | 3–1 | 0.4 | Philadelphia | 16,593 | Audi Field | Rubiel Vazquez | Match Report | |
| Sat | 2021-08-28 | 20:00 | Dynamo FC | 0.9 | 1–2 | 1.7 | Minnesota Utd | 14,521 | BBVA Stadium | Ted Unkel | Match Report | |
| Sat | 2021-08-28 | 20:00 | Sporting KC | 2.1 | 1–1 | 2.2 | Rapids | 19,883 | Children's Mercy Park | Fotis Bazakos | Match Report | |
| Sun | 2021-08-29 | 19:00 | Austin | 1.6 | 3–5 | 3.6 | FC Dallas | 20,738 | Q2 Stadium | Jair Marrufo | Match Report | |
| Sun | 2021-08-29 | 19:00 | Vancouver W'caps | 2.0 | 4–1 | 1.0 | RSL | 7,503 | BC Place Stadium | Ramy Touchan | Match Report | |
| Sun | 2021-08-29 | 19:30 | Seattle | 1.5 | 0–2 | 1.4 | Portland Timbers | 45,737 | Lumen Field | Alan Kelly | Match Report | |
| Fri | 2021-09-03 | 18:30 | Nashville | 1.0 | 3–1 | 1.7 | NYCFC | 20,126 | Nissan Stadium | Tim Ford | Match Report | |
| Fri | 2021-09-03 | 19:30 | Philadelphia | 1.2 | 0–1 | 1.4 | NE Revolution | 15,152 | Subaru Park | Jair Marrufo | Match Report | |
| Sat | 2021-09-04 | 16:00 | Vancouver W'caps | 2.0 | 2–1 | 1.4 | Austin | 9,223 | BC Place Stadium | Pierre-Luc Lauziere | Match Report | |
| Fri | 2021-09-03 | 19:00 | Dynamo FC | 1.2 | 0–2 | 2.1 | Portland Timbers | 9,872 | BBVA Stadium | Rubiel Vazquez | Match Report | |
| Fri | 2021-09-03 | 19:00 | LAFC | 3.5 | 4–0 | 0.4 | Sporting KC | 22,018 | Banc of California Stadium | Drew Fischer | Match Report | |
| Sat | 2021-09-04 | 19:30 | Orlando City | 1.6 | 3–2 | 0.8 | Crew | 15,366 | Exploria Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-09-04 | 18:00 | RSL | 2.5 | 3–2 | 1.3 | FC Dallas | 15,882 | Rio Tinto Stadium | Baldomero Toledo | Match Report | |
| Sat | 2021-09-04 | 19:00 | SJ Earthquakes | 1.3 | 0–1 | 1.5 | Rapids | 14,142 | Earthquakes Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-09-04 | 20:00 | FC Cincinnati | 0.7 | 0–1 | 1.1 | Inter Miami | 22,234 | TQL Stadium | Lukasz Szpala | Match Report | |
| Fri | 2021-09-10 | 19:00 | Atlanta Utd | 1.3 | 3–0 | 0.4 | Orlando City | 42,507 | Mercedes-Benz Stadium | Victor Rivas | Match Report | |
| Sat | 2021-09-11 | 14:00 | Seattle | 1.2 | 1–0 | 1.2 | Minnesota Utd | 33,130 | Lumen Field | Alex Chilowicz | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-09-11 | 15:30 | Rapids | 1.2 | 1–1 | 1.2 | LA Galaxy | 11,736 | Dick's Sporting Goods Park | Rosendo Mendoza | Match Report | |
| Fri | 2021-09-10 | 19:00 | Vancouver W'caps | 1.2 | 0–1 | 0.9 | Portland Timbers | BC Place Stadium | Marcos de Oliveira | Match Report | ||
| Sat | 2021-09-11 | 19:00 | NE Revolution | 1.9 | 2–1 | 0.8 | NYCFC | 19,481 | Gillette Stadium | Chris Penso | Match Report | |
| Sat | 2021-09-11 | 19:00 | NY Red Bulls | 0.7 | 1–1 | 2.0 | D.C. United | 12,574 | Red Bull Arena | Robert Sibiga | Match Report | |
| Sat | 2021-09-11 | 19:30 | Sporting KC | 2.2 | 2–0 | 1.1 | Fire | 18,467 | Children's Mercy Park | Jon Freemon | Match Report | |
| Sat | 2021-09-11 | 19:30 | FC Dallas | 1.4 | 1–1 | 1.6 | SJ Earthquakes | 15,237 | Toyota Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-09-11 | 19:30 | Dynamo FC | 1.6 | 3–0 | 1.1 | Austin | 14,070 | BBVA Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-09-11 | 20:00 | FC Cincinnati | 1.4 | 2–0 | 0.7 | Toronto FC | 22,636 | TQL Stadium | Dave Gantar | Match Report | |
| Sat | 2021-09-11 | 20:00 | Inter Miami | 0.7 | 1–0 | 0.6 | Crew | 15,014 | DRV PNK Stadium | Alan Kelly | Match Report | |
| Sat | 2021-09-11 | 20:00 | CF Montréal | 0.9 | 0–1 | 1.1 | Nashville | Stade Saputo | Silviu Petrescu | Match Report | ||
| Sun | 2021-09-12 | 19:30 | LAFC | 1.0 | 3–2 | 1.0 | RSL | 22,130 | Banc of California Stadium | Ted Unkel | Match Report | |
| Tue | 2021-09-14 | 19:30 | Toronto FC | 1.0 | 0–1 | 1.7 | Inter Miami | 7,970 | BMO Field | Ramy Touchan | Match Report | |
| Tue | 2021-09-14 | 19:30 | NYCFC | 2.2 | 3–3 | 1.5 | FC Dallas | Yankee Stadium | Joe Dickerson | Match Report | ||
| Tue | 2021-09-14 | 19:30 | Crew | 1.5 | 2–1 | 1.0 | NY Red Bulls | 17,358 | Lower.com Field | Jair Marrufo | Match Report | |
| Wed | 2021-09-15 | 19:00 | Atlanta Utd | 2.1 | 4–0 | 1.1 | FC Cincinnati | 42,501 | Mercedes-Benz Stadium | Drew Fischer | Match Report | |
| Wed | 2021-09-15 | 19:30 | Orlando City | 0.7 | 2–4 | 1.7 | CF Montréal | 14,133 | Exploria Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2021-09-15 | 19:30 | D.C. United | 2.0 | 3–0 | 1.6 | Fire | 13,524 | Audi Field | Dave Gantar | Match Report | |
| Wed | 2021-09-15 | 19:00 | Portland Timbers | 1.8 | 2–2 | 2.1 | Rapids | 16,808 | Providence Park | Armando Villarreal | Match Report | |
| Wed | 2021-09-15 | 19:30 | LA Galaxy | 1.1 | 1–1 | 1.3 | Dynamo FC | 15,341 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Wed | 2021-09-15 | 19:30 | Sporting KC | 2.2 | 4–0 | 1.1 | Minnesota Utd | 16,888 | Children's Mercy Park | Robert Sibiga | Match Report | |
| Wed | 2021-09-15 | 19:30 | SJ Earthquakes | 1.2 | 3–4 | 2.6 | RSL | 9,636 | Earthquakes Stadium | Nima Saghafi | Match Report | |
| Wed | 2021-09-15 | 20:00 | Austin | 1.3 | 1–2 | 2.5 | LAFC | 20,738 | Q2 Stadium | Tim Ford | Match Report | |
| Fri | 2021-09-17 | 19:00 | Inter Miami | 0.1 | 0–4 | 3.3 | NY Red Bulls | 18,535 | DRV PNK Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-09-18 | 15:30 | Atlanta Utd | 3.2 | 3–2 | 1.3 | D.C. United | 42,608 | Mercedes-Benz Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-09-18 | 19:00 | NE Revolution | 3.0 | 1–1 | 0.9 | Crew | 19,004 | Gillette Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-09-18 | 19:30 | Toronto FC | 1.2 | 2–1 | 1.8 | Nashville | 9,892 | BMO Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2021-09-18 | 19:30 | FC Cincinnati | 0.9 | 1–2 | 1.4 | NYCFC | 21,978 | TQL Stadium | Ted Unkel | Match Report | |
| Sun | 2021-09-19 | 13:00 | CF Montréal | 1.1 | 2–0 | 0.7 | Fire | Stade Saputo | Marcos de Oliveira | Match Report | ||
| Sun | 2021-09-19 | 16:00 | Philadelphia | 2.1 | 3–1 | 0.7 | Orlando City | 15,032 | Subaru Park | Alan Kelly | Match Report | |
| Sun | 2021-09-19 | 16:30 | Portland Timbers | 1.9 | 2–1 | 2.6 | LAFC | 21,311 | Providence Park | Chris Penso | Match Report | |
| Sat | 2021-09-18 | 19:00 | Minnesota Utd | 1.0 | 3–0 | 0.6 | LA Galaxy | 19,400 | Allianz Field | Jair Marrufo | Match Report | |
| Sat | 2021-09-18 | 19:00 | Austin | 2.5 | 3–4 | 2.8 | SJ Earthquakes | 20,738 | Q2 Stadium | Baldomero Toledo | Match Report | |
| Sat | 2021-09-18 | 19:30 | RSL | 1.9 | 1–0 | 0.5 | Seattle | 19,850 | Rio Tinto Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-09-18 | 20:30 | Dynamo FC | 2.2 | 3–2 | 1.6 | FC Dallas | 12,353 | BBVA Stadium | Victor Rivas | Match Report | |
| Sun | 2021-09-19 | 19:00 | Rapids | 2.1 | 1–1 | 0.9 | Vancouver W'caps | 8,454 | Dick's Sporting Goods Park | Rubiel Vazquez | Match Report | |
| Wed | 2021-09-22 | 19:30 | Inter Miami | 0.9 | 1–5 | 3.3 | Nashville | 13,033 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Wed | 2021-09-22 | 19:00 | Fire | 2.8 | 2–3 | 1.9 | NE Revolution | 7,052 | Soldier Field | Lukasz Szpala | Match Report | |
| Wed | 2021-09-22 | 20:00 | NY Red Bulls | 1.4 | 1–1 | 1.0 | NYCFC | 16,072 | Red Bull Arena | Ismail Elfath | Match Report | |
| Sat | 2021-09-25 | 15:30 | Philadelphia | 1.5 | 1–0 | 0.3 | Atlanta Utd | Subaru Park | Robert Sibiga | Match Report | ||
| Sat | 2021-09-25 | 19:00 | NE Revolution | 1.1 | 2–1 | 1.8 | Orlando City | 23,506 | Gillette Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-09-25 | 19:30 | NYCFC | 1.3 | 0–1 | 1.4 | NY Red Bulls | Yankee Stadium | Armando Villarreal | Match Report | ||
| Sat | 2021-09-25 | 19:30 | D.C. United | 2.4 | 4–2 | 1.2 | FC Cincinnati | 16,069 | Audi Field | Chris Penso | Match Report | |
| Sat | 2021-09-25 | 19:30 | Crew | 0.8 | 2–1 | 1.4 | CF Montréal | 19,423 | Lower.com Field | Nima Saghafi | Match Report | |
| Sun | 2021-09-26 | 12:00 | Fire | 0.2 | 0–0 | 0.5 | Nashville | 15,915 | Soldier Field | Ismir Pekmic | Match Report | |
| Sun | 2021-09-26 | 18:00 | Sporting KC | 0.5 | 1–2 | 1.1 | Seattle | 19,248 | Children's Mercy Park | Joe Dickerson | Match Report | |
| Sat | 2021-09-25 | 18:00 | Rapids | 0.7 | 0–0 | 0.5 | Toronto FC | 12,613 | Dick's Sporting Goods Park | Michael Radchuk | Match Report | |
| Sat | 2021-09-25 | 19:00 | Vancouver W'caps | 1.7 | 1–0 | 1.9 | FC Dallas | 16,927 | BC Place Stadium | Kevin Stott | Match Report | |
| Sat | 2021-09-25 | 19:00 | Minnesota Utd | 1.3 | 2–0 | 1.6 | Dynamo FC | 19,471 | Allianz Field | Allen Chapman | Match Report | |
| Sat | 2021-09-25 | 19:00 | SJ Earthquakes | 1.7 | 2–0 | 1.3 | LAFC | 16,927 | Earthquakes Stadium | Jair Marrufo | Match Report | |
| Sat | 2021-09-25 | 19:30 | Portland Timbers | 1.7 | 6–1 | 1.7 | RSL | 21,579 | Providence Park | Fotis Bazakos | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-09-26 | 20:30 | Austin | 1.0 | 2–0 | 1.2 | LA Galaxy | Q2 Stadium | Guido Gonzalez Jr. | Match Report | ||
| Wed | 2021-09-29 | 19:00 | Toronto FC | 3.4 | 3–2 | 0.8 | FC Cincinnati | 5,110 | BMO Field | Silviu Petrescu | Match Report | |
| Wed | 2021-09-29 | 19:00 | Atlanta Utd | 2.4 | 1–0 | 0.6 | Inter Miami | 42,519 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Wed | 2021-09-29 | 19:30 | D.C. United | 3.4 | 3–1 | 0.3 | Minnesota Utd | 12,262 | Audi Field | Ramy Touchan | Match Report | |
| Wed | 2021-09-29 | 19:30 | NY Red Bulls | 0.7 | 1–1 | 1.0 | Philadelphia | 9,193 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Wed | 2021-09-29 | 19:30 | CF Montréal | 1.8 | 1–4 | 1.9 | NE Revolution | Stade Saputo | Ismail Elfath | Match Report | ||
| Wed | 2021-09-29 | 19:00 | FC Dallas | 1.2 | 1–3 | 1.9 | Sporting KC | 12,387 | Toyota Stadium | Jair Marrufo | Match Report | |
| Wed | 2021-09-29 | 19:00 | Fire | 1.3 | 2–0 | 0.6 | NYCFC | 5,593 | Soldier Field | Baldomero Toledo | Match Report | |
| Wed | 2021-09-29 | 19:00 | Rapids | 1.2 | 3–0 | 0.5 | Austin | 8,582 | Dick's Sporting Goods Park | Michael Radchuk | Match Report | |
| Wed | 2021-09-29 | 19:30 | SJ Earthquakes | 0.8 | 1–3 | 2.2 | Seattle | 11,361 | Earthquakes Stadium | Allen Chapman | Match Report | |
| Wed | 2021-09-29 | 19:30 | LAFC | 1.2 | 1–2 | 1.1 | Portland Timbers | 22,056 | Banc of California Stadium | Joe Dickerson | Match Report | |
| Wed | 2021-09-29 | 19:30 | Nashville | 1.7 | 2–2 | 1.2 | Orlando City | 18,648 | Nissan Stadium | Drew Fischer | Match Report | |
| Wed | 2021-09-29 | 19:30 | RSL | 1.0 | 2–1 | 1.9 | LA Galaxy | 18,121 | Rio Tinto Stadium | Tori Penso | Match Report | |
| Wed | 2021-09-29 | 20:00 | Dynamo FC | 1.9 | 0–0 | 0.2 | Vancouver W'caps | 12,114 | BBVA Stadium | Alan Kelly | Match Report | |
| Sat | 2021-10-02 | 14:30 | Austin | 3.1 | 2–1 | 1.3 | RSL | Q2 Stadium | Rosendo Mendoza | Match Report | ||
| Sat | 2021-10-02 | 19:00 | CF Montréal | 1.9 | 2–1 | 1.1 | Atlanta Utd | Stade Saputo | Fotis Bazakos | Match Report | ||
| Sat | 2021-10-02 | 19:30 | Orlando City | 1.4 | 2–1 | 0.6 | D.C. United | 16,848 | Exploria Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-10-02 | 19:30 | FC Cincinnati | 0.5 | 0–1 | 1.3 | NY Red Bulls | 22,141 | TQL Stadium | Tim Ford | Match Report | |
| Sun | 2021-10-03 | 12:00 | NYCFC | 2.0 | 0–0 | 0.9 | Nashville | Red Bull Arena | Marcos de Oliveira | Match Report | ||
| Sun | 2021-10-03 | 14:30 | Portland Timbers | 2.1 | 1–0 | 0.8 | Inter Miami | 22,006 | Providence Park | Robert Sibiga | Match Report | |
| Sun | 2021-10-03 | 15:00 | Sporting KC | 3.5 | 4–2 | 1.9 | Dynamo FC | 17,867 | Children's Mercy Park | Alex Chilowicz | Match Report | |
| Sun | 2021-10-03 | 16:00 | Philadelphia | 1.2 | 3–0 | 1.4 | Crew | 15,578 | Subaru Park | Victor Rivas | Match Report | |
| Sun | 2021-10-03 | 16:00 | Toronto FC | 2.7 | 3–1 | 0.8 | Fire | BMO Field | Nima Saghafi | Match Report | ||
| Sat | 2021-10-02 | 19:00 | FC Dallas | 1.1 | 0–0 | 1.4 | Minnesota Utd | 17,231 | Toyota Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2021-10-02 | 19:00 | Vancouver W'caps | 2.5 | 3–0 | 0.6 | SJ Earthquakes | BC Place Stadium | Pierre-Luc Lauziere | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-10-03 | 17:00 | LA Galaxy | 1.6 | 1–1 | 1.3 | LAFC | 25,174 | Dignity Health Sports Park | Armando Villarreal | Match Report | |
| Sun | 2021-10-03 | 19:00 | Seattle | 1.4 | 3–0 | 0.9 | Rapids | 31,425 | Lumen Field | Chris Penso | Match Report | |
| Sat | 2021-10-09 | 18:00 | NY Red Bulls | 2.3 | 1–0 | 0.3 | Inter Miami | 17,516 | Red Bull Arena | Tori Penso | Match Report | |
| Sun | 2021-10-10 | 15:00 | Minnesota Utd | 1.4 | 1–3 | 2.6 | Rapids | Allianz Field | Jon Freemon | Match Report | ||
| Sat | 2021-10-09 | 18:00 | Seattle | 1.9 | 4–1 | 2.1 | Vancouver W'caps | 31,842 | Lumen Field | Ted Unkel | Match Report | |
| Sat | 2021-10-09 | 20:00 | FC Cincinnati | 1.7 | 1–2 | 1.3 | Philadelphia | 21,674 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2021-10-16 | 12:30 | LAFC | 2.8 | 3–1 | 2.4 | SJ Earthquakes | 22,003 | Banc of California Stadium | Alan Kelly | Match Report | |
| Sat | 2021-10-16 | 13:00 | CF Montréal | 0.8 | 2–2 | 0.2 | Philadelphia | Stade Saputo | Pierre-Luc Lauziere | Match Report | ||
| Sat | 2021-10-16 | 18:00 | Crew | 2.5 | 4–0 | 0.7 | Inter Miami | 19,338 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2021-10-16 | 19:00 | NE Revolution | 1.4 | 2–2 | 1.1 | Fire | 28,414 | Gillette Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-10-16 | 19:30 | Toronto FC | 1.4 | 0–2 | 1.8 | Atlanta Utd | 7,490 | BMO Field | Tim Ford | Match Report | |
| Sat | 2021-10-16 | 19:30 | D.C. United | 1.1 | 0–0 | 0.3 | Nashville | 18,034 | Audi Field | Ismail Elfath | Match Report | |
| Sat | 2021-10-16 | 19:30 | FC Cincinnati | 0.6 | 0–1 | 1.1 | Orlando City | 22,488 | TQL Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2021-10-17 | 13:00 | NY Red Bulls | 1.9 | 1–0 | 0.6 | NYCFC | 18,613 | Red Bull Arena | Jair Marrufo | Match Report | |
| Sat | 2021-10-16 | 19:30 | Dynamo FC | 1.1 | 2–1 | 1.2 | Seattle | 14,265 | BBVA Stadium | Nima Saghafi | Match Report | |
| Sat | 2021-10-16 | 19:30 | RSL | 1.2 | 3–1 | 0.7 | Rapids | Rio Tinto Stadium | Kevin Stott | Match Report | ||
| Sat | 2021-10-16 | 19:30 | LA Galaxy | 3.1 | 2–1 | 0.4 | Portland Timbers | 15,322 | Dignity Health Sports Park | Victor Rivas | Match Report | |
| Sat | 2021-10-16 | 20:00 | Austin | 1.5 | 0–1 | 1.8 | Minnesota Utd | 20,738 | Q2 Stadium | Michael Radchuk | Match Report | |
| Sun | 2021-10-17 | 19:00 | Vancouver W'caps | 0.6 | 2–1 | 0.4 | Sporting KC | 10,990 | BC Place Stadium | Silviu Petrescu | Match Report | |
| Wed | 2021-10-20 | 19:30 | Orlando City | 1.4 | 1–1 | 0.8 | CF Montréal | 15,775 | Exploria Stadium | Robert Sibiga | Match Report | |
| Wed | 2021-10-20 | 19:30 | D.C. United | 2.1 | 2–3 | 1.9 | NE Revolution | 13,387 | Audi Field | Nima Saghafi | Match Report | |
| Wed | 2021-10-20 | 19:30 | Atlanta Utd | 1.0 | 1–1 | 0.9 | NYCFC | 42,511 | Mercedes-Benz Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2021-10-20 | 19:30 | FC Cincinnati | 2.6 | 3–4 | 2.3 | Fire | 21,369 | TQL Stadium | Jon Freemon | Match Report | |
| Wed | 2021-10-20 | 19:30 | Inter Miami | 1.5 | 3–0 | 0.7 | Toronto FC | DRV PNK Stadium | Armando Villarreal | Match Report | ||
| Wed | 2021-10-20 | 19:00 | Minnesota Utd | 1.5 | 3–2 | 2.2 | Philadelphia | Allianz Field | Allen Chapman | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-10-20 | 19:00 | FC Dallas | 2.0 | 2–3 | 1.8 | LAFC | 12,532 | Toyota Stadium | Chris Penso | Match Report | |
| Wed | 2021-10-20 | 19:00 | Rapids | 1.2 | 1–1 | 1.4 | Seattle | 9,316 | Dick's Sporting Goods Park | Drew Fischer | Match Report | |
| Wed | 2021-10-20 | 19:00 | Portland Timbers | 1.2 | 2–3 | 1.8 | Vancouver W'caps | 16,722 | Providence Park | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-10-20 | 19:30 | SJ Earthquakes | 2.6 | 4–0 | 1.0 | Austin | 12,035 | Earthquakes Stadium | Ismir Pekmic | Match Report | |
| Wed | 2021-10-20 | 19:30 | Nashville | 1.1 | 1–1 | 0.6 | Crew | 18,381 | Nissan Stadium | Alex Chilowicz | Match Report | |
| Wed | 2021-10-20 | 19:30 | Dynamo FC | 2.1 | 0–3 | 1.8 | LA Galaxy | 13,798 | BBVA Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-10-23 | 12:30 | Seattle | 1.7 | 1–2 | 1.2 | Sporting KC | 32,139 | Lumen Field | Ismail Elfath | Match Report | |
| Sat | 2021-10-23 | 18:00 | Crew | 0.6 | 1–2 | 2.5 | NY Red Bulls | 17,891 | Lower.com Field | Alan Kelly | Match Report | |
| Sat | 2021-10-23 | 19:30 | Philadelphia | 1.8 | 1–0 | 0.3 | Nashville | 18,575 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2021-10-23 | 19:30 | NYCFC | 3.1 | 6–0 | 0.7 | D.C. United | Yankee Stadium | Joe Dickerson | Match Report | ||
| Sat | 2021-10-23 | 19:30 | Toronto FC | 2.2 | 1–1 | 2.1 | CF Montréal | 8,095 | BMO Field | Allen Chapman | Match Report | |
| Sun | 2021-10-24 | 16:00 | Austin | 1.9 | 2–1 | 0.8 | Dynamo FC | Q2 Stadium | Tim Ford | Match Report | ||
| Sat | 2021-10-23 | 19:00 | LA Galaxy | 2.0 | 2–2 | 1.5 | FC Dallas | 15,136 | Dignity Health Sports Park | Baldomero Toledo | Match Report | |
| Sat | 2021-10-23 | 19:00 | Rapids | 1.4 | 2–0 | 0.4 | Portland Timbers | 12,200 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2021-10-23 | 19:00 | SJ Earthquakes | 1.4 | 1–1 | 0.7 | Vancouver W'caps | 15,025 | Earthquakes Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-10-23 | 19:00 | Minnesota Utd | 2.2 | 1–1 | 0.6 | LAFC | 19,406 | Allianz Field | Robert Sibiga | Match Report | |
| Sat | 2021-10-23 | 19:00 | Fire | 2.0 | 1–0 | 1.2 | RSL | 31,308 | Soldier Field | Rosendo Mendoza | Match Report | |
| Sun | 2021-10-24 | 19:30 | Orlando City | 2.0 | 2–2 | 1.3 | NE Revolution | 17,539 | Exploria Stadium | Chris Penso | Match Report | |
| Sat | 2021-10-23 | 20:00 | Inter Miami | 2.1 | 5–1 | 1.8 | FC Cincinnati | 14,927 | DRV PNK Stadium | Drew Fischer | Match Report | |
| Wed | 2021-10-27 | 19:00 | NE Revolution | 1.5 | 1–0 | 0.7 | Rapids | 10,199 | Gillette Stadium | Victor Rivas | Match Report | |
| Wed | 2021-10-27 | 19:30 | D.C. United | 0.9 | 1–0 | 2.2 | NY Red Bulls | 14,109 | Audi Field | Rubiel Vazquez | Match Report | |
| Wed | 2021-10-27 | 19:30 | FC Cincinnati | 2.4 | 3–6 | 1.8 | Nashville | 20,581 | TQL Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-10-27 | 19:30 | NYCFC | 2.1 | 1–0 | 0.5 | Fire | Red Bull Arena | Fotis Bazakos | Match Report | ||
| Tue | 2021-10-26 | 19:30 | LAFC | 1.1 | 3–0 | 1.7 | Seattle | 22,030 | Banc of California Stadium | Kevin Stott | Match Report | |
| Wed | 2021-10-27 | 19:30 | Toronto FC | 1.3 | 2–2 | 2.0 | Philadelphia | 5,026 | BMO Field | Silviu Petrescu | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-10-27 | 19:30 | Atlanta Utd | 1.5 | 2–1 | 2.1 | Inter Miami | 42,536 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-10-27 | 19:30 | Crew | 1.7 | 3–2 | 1.7 | Orlando City | 16,676 | Lower.com Field | Joe Dickerson | Match Report | |
| Wed | 2021-10-27 | 19:00 | Portland Timbers | 3.2 | 2–0 | 1.2 | SJ Earthquakes | 16,086 | Providence Park | Alex Chilowicz | Match Report | |
| Wed | 2021-10-27 | 19:00 | Vancouver W'caps | 1.0 | 2–1 | 2.3 | Minnesota Utd | 10,833 | BC Place Stadium | Nima Saghafi | Match Report | |
| Wed | 2021-10-27 | 19:00 | FC Dallas | 1.7 | 1–2 | 1.3 | RSL | 12,486 | Toyota Stadium | Ismail Elfath | Match Report | |
| Wed | 2021-10-27 | 19:30 | Sporting KC | 0.7 | 2–0 | 0.7 | LA Galaxy | 18,711 | Children's Mercy Park | Alan Kelly | Match Report | |
| Sat | 2021-10-30 | 13:30 | RSL | 2.3 | 3–4 | 2.7 | SJ Earthquakes | 15,553 | Rio Tinto Stadium | Jon Freemon | Match Report | |
| Sat | 2021-10-30 | 13:30 | Inter Miami | 1.1 | 1–3 | 1.4 | NYCFC | 17,595 | DRV PNK Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-10-30 | 16:00 | NY Red Bulls | 1.4 | 1–0 | 0.9 | CF Montréal | 16,344 | Red Bull Arena | Chris Penso | Match Report | |
| Sat | 2021-10-30 | 18:00 | Atlanta Utd | 2.4 | 1–1 | 0.9 | Toronto FC | 43,372 | Mercedes-Benz Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-10-30 | 19:30 | D.C. United | 0.9 | 1–3 | 2.7 | Crew | 16,787 | Audi Field | Drew Fischer | Match Report | |
| Sun | 2021-10-31 | 12:00 | Minnesota Utd | 1.8 | 2–1 | 0.6 | Sporting KC | Allianz Field | Victor Rivas | Match Report | ||
| Sun | 2021-10-31 | 14:00 | Dynamo FC | 0.6 | 0–1 | 0.4 | Rapids | 14,474 | BBVA Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-10-31 | 16:00 | Orlando City | 1.0 | 1–1 | 0.8 | Nashville | 15,959 | Exploria Stadium | Allen Chapman | Match Report | |
| Sun | 2021-10-31 | 19:30 | Philadelphia | 2.8 | 2–0 | 0.5 | FC Cincinnati | 13,488 | Subaru Park | Fotis Bazakos | Match Report | |
| Sat | 2021-10-30 | 20:00 | FC Dallas | 1.6 | 2–1 | 0.5 | Austin | 16,080 | Toyota Stadium | Silviu Petrescu | Match Report | |
| Mon | 2021-11-01 | 19:00 | Seattle | 1.4 | 1–1 | 1.1 | LA Galaxy | 32,781 | Lumen Field | Joe Dickerson | Match Report | |
| Wed | 2021-11-03 | 19:30 | NY Red Bulls | 1.3 | 0–0 | 0.2 | Atlanta Utd | 15,934 | Red Bull Arena | Alan Kelly | Match Report | |
| Tue | 2021-11-02 | 19:30 | LAFC | 3.1 | 1–1 | 0.8 | Vancouver W'caps | 22,221 | Banc of California Stadium | Alex Chilowicz | Match Report | |
| Wed | 2021-11-03 | 19:30 | CF Montréal | 1.3 | 2–0 | 0.7 | Dynamo FC | Stade Saputo | Ted Unkel | Match Report | ||
| Wed | 2021-11-03 | 20:00 | Austin | 2.0 | 3–1 | 0.7 | Sporting KC | 20,738 | Q2 Stadium | Nima Saghafi | Match Report | |
| Wed | 2021-11-03 | 20:30 | RSL | 2.2 | 1–3 | 1.8 | Portland Timbers | 18,405 | Rio Tinto Stadium | Chris Penso | Match Report | |
| Sun | 2021-11-07 | 14:30 | Nashville | 1.0 | 1–1 | 1.6 | NY Red Bulls | 26,913 | Nissan Stadium | Drew Fischer | Match Report | |
| Sun | 2021-11-07 | 15:00 | LA Galaxy | 2.1 | 3–3 | 2.6 | Minnesota Utd | 23,803 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Sun | 2021-11-07 | 15:00 | SJ Earthquakes | 2.6 | 1–1 | 1.6 | FC Dallas | Earthquakes Stadium | Victor Rivas | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-11-07 | 15:00 | Portland Timbers | 4.2 | 3–0 | 0.4 | Austin | 23,127 | Providence Park | Rosendo Mendoza | Match Report | |
| Sun | 2021-11-07 | 15:00 | Vancouver W'caps | 1.0 | 1–1 | 1.6 | Seattle | 25,117 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-11-07 | 15:30 | NE Revolution | 2.0 | 0–1 | 0.5 | Inter Miami | 31,635 | Gillette Stadium | Alan Kelly | Match Report | |
| Sun | 2021-11-07 | 15:30 | FC Cincinnati | 0.6 | 1–2 | 2.3 | Atlanta Utd | 23,663 | TQL Stadium | Nima Saghafi | Match Report | |
| Sun | 2021-11-07 | 15:30 | Crew | 4.0 | 2–0 | 0.7 | Fire | 19,351 | Lower.com Field | Tim Ford | Match Report | |
| Sun | 2021-11-07 | 15:30 | CF Montréal | 1.4 | 0–2 | 0.7 | Orlando City | Stade Saputo | Armando Villarreal | Match Report | ||
| Sun | 2021-11-07 | 15:30 | NYCFC | 0.6 | 1–1 | 1.6 | Philadelphia | Yankee Stadium | Guido Gonzalez Jr. | Match Report | ||
| Sun | 2021-11-07 | 15:30 | Toronto FC | 1.4 | 1–3 | 2.6 | D.C. United | 11,166 | BMO Field | Marcos de Oliveira | Match Report | |
| Sun | 2021-11-07 | 16:00 | Rapids | 3.1 | 5–2 | 1.8 | LAFC | 16,292 | Dick's Sporting Goods Park | Allen Chapman | Match Report | |
| Sun | 2021-11-07 | 17:00 | Sporting KC | 1.3 | 0–1 | 1.5 | RSL | 19,022 | Children's Mercy Park | Ted Unkel | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First Round | Sat | 2021-11-20 | 14:30 | Philadelphia | 2.0 | 1–0 | 0.9 | NY Red Bulls | 18,623 | Subaru Park | Fotis Bazakos | Match Report | Required Extra Time |
| First Round | Sat | 2021-11-20 | 16:00 | Sporting KC | 1.4 | 3–1 | 1.1 | Vancouver W'caps | 19,817 | Children's Mercy Park | Alan Kelly | Match Report | |
| First Round | Sun | 2021-11-21 | 14:30 | Portland Timbers | 2.3 | 3–1 | 1.7 | Minnesota Utd | 22,533 | Providence Park | Armando Villarreal | Match Report | |
| First Round | Sun | 2021-11-21 | 15:00 | NYCFC | 1.1 | 2–0 | 0.4 | Atlanta Utd | 25,267 | Yankee Stadium | Chris Penso | Match Report | |
| First Round | Tue | 2021-11-23 | 19:00 | Nashville | 0.5 | 3–1 | 0.5 | Orlando City | 26,043 | Nissan Stadium | Ismail Elfath | Match Report | |
| First Round | Tue | 2021-11-23 | 19:30 | Seattle | 1.1 | (5) 0–0 (6) | 0.0 | RSL | 34,012 | Lumen Field | Joe Dickerson | Match Report | RSL won on penalty kicks following extra time |
| Conference Semifinals | Thu | 2021-11-25 | 14:30 | Rapids | 1.2 | 0–1 | 2.0 | Portland Timbers | 17,438 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Conference Semifinals | Sun | 2021-11-28 | 14:00 | Sporting KC | 1.0 | 1–2 | 1.1 | RSL | 21,650 | Children's Mercy Park | Kevin Stott | Match Report | |
| Conference Semifinals | Sun | 2021-11-28 | 17:30 | Philadelphia | 2.0 | (2) 1–1 (0) | 0.9 | Nashville | 19,076 | Subaru Park | Allen Chapman | Match Report | Philadelphia won on penalty kicks following extra time |
| Conference Semifinals | Tue | 2021-11-30 | 19:30 | NE Revolution | 1.1 | (3) 2–2 (5) | 0.9 | NYCFC | 25,509 | Gillette Stadium | Drew Fischer | Match Report | NYCFC won on penalty kicks following extra time |
| Conference Finals | Sat | 2021-12-04 | 15:30 | Portland Timbers | 1.3 | 2–0 | 0.4 | RSL | Providence Park | Alan Kelly | Match Report | ||
| Conference Finals | Sun | 2021-12-05 | 15:00 | Philadelphia | 0.7 | 1–2 | 1.6 | NYCFC | 19,487 | Subaru Park | Ted Unkel | Match Report | |
| MLS Cup | Sat | 2021-12-11 | 12:00 | Portland Timbers | 1.3 | (2) 1–1 (4) | 0.9 | NYCFC | 25,218 | Providence Park | Armando Villarreal | Match Report | NYCFC won on penalty kicks following extra time |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
FBref is the most complete sources for women's football data on the internet. This includes the entire history of the FIFA Women's World Cup as well as recent domestic league seasons from nine countries, including advanced stats like xG for most of those nine.
In collaboration with Opta, we are including advanced analytical data such as xG, xA, progressive passing, duels and more for over twenty competitions. For more information on the expected goals model and which competitions have advanced data, see our xG explainer.
Note that player records are likely not complete for their careers. Players may come from or move to leagues we don't currently cover. This issue will go down over time, as we add new leagues and seasons. We will never in the future have less data than we do today.
You can sign up to receive an e-mail when new countries and features launch.
For more information, see our Launch Blog Post, the overall leagues/competition page with details on leagues and seasons we include, or our About Page. Let us know if you find an issue or have a suggestion.
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